CAS Number514-65-8
SynonymsBiperidene [INN-French]; 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol; EINECS 208-184-6; Biperideno; 1-norborn-5-en-2-yl-1-phenyl-3-piperidino-propan-1-ol; Biperidene; Biperidine; Beperiden; a-5-Norbornen-2-yl-a-phenyl-1-piperidinepropanol; biperiden; 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol; 1-norborn-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol; 3-Piperidino-1-phenyl-(D5-bicyclo[2.2.1]hepten-2-yl)-1-propanol; Akineton; 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol; 1-Bicycloheptenyl-1-phenyl-3-piperidinopropanol; Biperidenum; a-Bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-1-piperidinepropanol; Biperideno [INN-Spanish]; Biperidenum [INN-Latin]; 1-[(1R,4R)-Bicyclo[2.2.1]hept-5-en-2-yl]-1-phenyl-3-(1-piperidinyl)-1-pro
Molecular FormulaC21H29NO
Molecular Weight311.461
Purity98.00%
Density1.1±0.1 g/cm3
Boiling Point462.1±40.0 °C at 760 mmHg
Melting Point114ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 514-65-8 |
| Catalog No. | 2A-9022421 |
| Chinese Name | 比哌立登 |
| Synonyms | Biperidene [INN-French]; 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol; EINECS 208-184-6; Biperideno; 1-norborn-5-en-2-yl-1-phenyl-3-piperidino-propan-1-ol; Biperidene; Biperidine; Beperiden; a-5-Norbornen-2-yl-a-phenyl-1-piperidinepropanol; biperiden; 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol; 1-norborn-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol; 3-Piperidino-1-phenyl-(D5-bicyclo[2.2.1]hepten-2-yl)-1-propanol; Akineton; 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol; 1-Bicycloheptenyl-1-phenyl-3-piperidinopropanol; Biperidenum; a-Bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-1-piperidinepropanol; Biperideno [INN-Spanish]; Biperidenum [INN-Latin]; 1-[(1R,4R)-Bicyclo[2.2.1]hept-5-en-2-yl]-1-phenyl-3-(1-piperidinyl)-1-pro |
| Molecular Formula | C21H29NO |
| Molecular Weight | 311.461 |
| Purity | 98.00 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 462.1±40.0 °C at 760 mmHg |
| Melting Point | 114ºC |
| Water Solubility | 25.1 mg/L |
| Storage Condition | Ventilated low-temperature drying |
| Application | Biperiden (KL 373) has anti-Parkinson's activity and is a central M1 choline receptor blocker. |
| HTC | 2933399090 |
| SMILES | OC(CCN1CCCCC1)(c1ccccc1)C1CC2C=CC1C2 |
| InChI | InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2 |
| InChI Key | YSXKPIUOCJLQIE-UHFFFAOYSA-N |
| MSDS | msds/22421_1_514_65_8.pdf |
| Use of | Properties Name biperiden Synonym More Synonyms biperiden Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease References [1]. Pehl C, et al. Effects of two anticholinergic drugs, trospium chloride and biperiden, on motility and evoked potentials of the oesophagus. Aliment Pharmacol Ther. 1998 Oct;12(10) [2]. Kornhuber J, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8) [3]. Myhrer T, et al. Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. Pharmacol Biochem Behav. 2008 Jun;89(4):633-8. Chemical & Physical Properties Molecular Formula C21H29NO Exact Mass 311.224915 PSA 23.47000 Index of Refraction 1.583 InChIKey YSXKPIUOCJLQIE-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1-Piperidinepropanol, alpha-5-norbornen-2-yl-alpha-phenyl- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C21-H29-N-O MOLECULAR WEIGHT : WISWESSER LINE NOTATION : L55 A CUTJ FXQR&2- AT6NTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,636,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,636,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,636,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,204,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,204,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,636,1982 Safety Information RIDADR NONH for all modes of transport HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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