CAS Number510-77-0
SynonymsGalanthaminone; (+)-narwedine; 6-methoxy-10-methyl-galantham-1-en-3-one; Narwedine; (-)-Narwedine
Molecular FormulaC17H19O3N1
Molecular Weight285.34
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point397.4±42.0 °C at 760 mmHg
Melting Point175-180ºC (dec.)
Appearancewhite to off-white chemistry
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 510-77-0 |
| Catalog No. | 2A-9022393 |
| Chinese Name | 那维定 |
| Synonyms | Galanthaminone; (+)-narwedine; 6-methoxy-10-methyl-galantham-1-en-3-one; Narwedine; (-)-Narwedine |
| Molecular Formula | C17H19O3N1 |
| Molecular Weight | 285.34 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 397.4±42.0 °C at 760 mmHg |
| Melting Point | 175-180ºC (dec.) |
| Appearance | white to off-white chemistry |
| Storage Condition | -20°C Freezer |
| Application | Galanthaminone is a competitive and reversible cholinesterase (AChE) inhibitor that can act on a variety of memory disorders. |
| HTC | 2942000000 |
| MDL Number | MFCD13193038 |
| SMILES | COc1ccc2c3c1OC1CC(=O)C=CC31CCN(C)C2 |
| InChI | InChI=1S/C17H19NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,14H,7-10H2,1-2H3/t14-,17-/m1/s1 |
| InChI Key | QENVUHCAYXAROT-YOEHRIQHSA-N |
| MSDS | msds/22393_1_510_77_0.pdf |
| Use of | Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments. Properties Name N6-p-Methoxyphenyladenosin Synonym More Synonyms Galanthaminone Biological Activity Description Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments. Related Catalog Signaling Pathways >> Neuronal Signaling >> AChE Research Areas >> Neurological Disease In Vitro Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release. References [1]. Greenblatt HM, et al. Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution. FEBS Lett. 1999 Dec 17;463(3):321-6. [2]. Heinrich M, et al. Galanthamine from snowdrop--the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol. 2004 Jun;92(2-3):147-62. Chemical & Physical Properties Molecular Formula C17H19NO3 Exact Mass 285.136505 PSA 38.77000 Index of Refraction 1.626 InChIKey QENVUHCAYXAROT-YOEHRIQHSA-N Safety Information HS Code 2942000000 Synthetic Route Galantamine Galanthaminone Literature: Lee; Goehring; Ma Journal of Organic Chemistry, 1998 , vol. 63, # 13 p. 4535 - 4536 Galanthaminone Galanthaminone Literature: Trinadhachari, Ganala Naga; Kamat, Anand Gopalkrishna; Prabahar, Koilpillai Joseph; Handa, Vijay Kumar; Srinu, Kukunuri Naga Venkata Satya; Babu, Korupolu Raghu; Sanasi, Paul Douglas Organic Process Research and Development, 2013 , vol. 17, # 3 p. 406 - 412 4a,5,9,10,11,12... 296237-49-5 Galanthaminone Precursor & DownStream Precursor 10 CAS#:357-70-0 Galantamine CAS#:510-77-0 Galanthaminone CAS#:296237-49-5 4a,5,9,10,11,12... CAS#:122584-14-9 (4aR,8aR)-1-Bro... DownStream 4 CAS#:357-70-0 Galantamine CAS#:510-77-0 Galanthaminone CAS#:1953-04-4 Galantamine hyd... CAS#:1668-85-5 Epi-galantamine |
| Transport Info | Product Name: Galantamine |
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