CAS Number6631-94-3
Synonyms2-acetyl-1-phenothiazine; EINECS 229-626-4; 2-Acetyl-10H-phenothiazine; 1-phenothiazin-2-yl-ethanone; 2-acetyl-phenothiazine; MFCD00005017; 1-(10H-phenothiazin-2-yl)ethanone; methyl phenothiazin-2-yl ketone; ML171
Molecular FormulaC14H11NOS
Molecular Weight241.31
Purity95%
Density1.249 g/cm3
Boiling Point455.7ºC at 760 mmHg
Melting Point180-185 °C (lit.)
Appearancepowder
EINECS229-626-4
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6631-94-3 |
| Catalog No. | 2A-9002217 |
| Chinese Name | 2-乙酰基吩噻嗪 |
| Synonyms | 2-acetyl-1-phenothiazine; EINECS 229-626-4; 2-Acetyl-10H-phenothiazine; 1-phenothiazin-2-yl-ethanone; 2-acetyl-phenothiazine; MFCD00005017; 1-(10H-phenothiazin-2-yl)ethanone; methyl phenothiazin-2-yl ketone; ML171 |
| Molecular Formula | C14H11NOS |
| Molecular Weight | 241.31 |
| Purity | 95 |
| Density | 1.249 g/cm3 |
| Boiling Point | 455.7ºC at 760 mmHg |
| Melting Point | 180-185 °C (lit.) |
| Appearance | powder |
| Water Solubility | Soluble in: dimethylformamide |
| Storage Condition | Store in airtight, cool and dry place |
| Application | ML171 (2-Acetylphenothiazine; 2-APT) is a potent and selective Nox1 inhibitor that blocks Nox-1-dependent ROS production, with an IC50 value of 0.25 μM in the HEK293-Nox1 validation assay. |
| EINECS | 229-626-4 |
| HTC | 2934300000 |
| PubChem ID | 24850493 |
| MDL Number | MFCD00005017 |
| SMILES | CC(=O)c1ccc2Sc3ccccc3Nc2c1 |
| InChI | 1S/C14H11NOS/c1-9(16)10-6-7-14-12(8-10)15-11-4-2-3-5-13(11)17-14/h2-8,15H,1H3 |
| InChI Key | JWGBOHJGWOPYCL-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/2217_1_6631_94_3.pdf |
| Use of | Properties Name 2-Acetylphenothiazine Synonym More Synonyms ML171 Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease IC50: 0.25 μM (HEK293-Nox1), 0.129 μM (HT29)[1] References [1]. Gianni D, et al. A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. ACS Chem Biol. 2010 Oct 15;5(10):981-93. Chemical & Physical Properties Molecular Formula C14H11NOS Exact Mass 241.05600 PSA 54.40000 LogP 4.23540 Index of Refraction 1.653 InChIKey JWGBOHJGWOPYCL-UHFFFAOYSA-N Safety Information Hazard Codes Xn Safety Phrases 60-61 WGK Germany 3 HS Code 2934300000 Synthetic Route Ethanone,1,1... Literature: Bulletin de la Societe Chimique de France, , p. 768,781 Ethanone,1-(10H... Literature: Journal of Medicinal Chemistry, , vol. 41, # 2 p. 148 - 156 Phenothiazine Literature: Journal of Medicinal Chemistry, , vol. 41, # 2 p. 148 - 156 Precursor & DownStream Precursor 9 CAS#:6632-11-7 Ethanone,1,1'-(... CAS#:1628-29-1 Ethanone,1-(10H... CAS#:92-84-2 Phenothiazine CAS#:75-36-5 Acetyl chloride DownStream 10 CAS#:1053-74-3 2-Acetyl-10-[3-... CAS#:21896-43-5 2-ethenyl-10H-p... CAS#:63285-46-1 3-(Dimethylamin... CAS#:63285-55-2 2-(1H-Pyrazol-3... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| 2-Acetyl-5-bromo-6-methoxynaphthalene | 84167-74-8 | 2A-9002208 |
| 2-Acetyl-5-hydroxy-3-oxo-4-hexenoic acid delta-lactone | 520-45-6 | 2A-9002210 |
| 2-Acetyl-5-hydroxy-3-oxo-4-hexenoic acid delta-lactone sodium salt | 4418-26-2 | 2A-9002211 |
| 2-Acetyl-6-methoxynaphthalene | 3900-45-6 | 2A-9002212 |
| 2-Acetylaminomalonic acid diethyl ester | 1068-90-2 | 2A-9002214 |
| 2-Adamantanol | 700-57-2 | 2A-9002222 |
| 2-Amino-1-[4-(2-hydroxyethyl)piperazin-1-yl]ethanone dihydrochloride | 717904-39-7 | 2A-9002227 |
| 2-Amino-2-(4'-fluorophenyl)acetonitrile | 56464-70-1 | 2A-9002229 |
| 2-Amino-2',4'-dichloroacetophenone | 313553-17-2 | 2A-9002230 |
| 2-Amino-2',4'-difluoroacetophenone | 643029-92-9 | 2A-9002231 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS