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Home > Products > Pharmaceutical R&D Materials > Heterocyclic Building Blocks > 2-{[4(3-Methoxypropoxy)-3-methyl pyridine-2-yl]methylthio}-1H-benzimidazole
2-{[4(3-Methoxypropoxy)-3-methyl pyridine-2-yl]methylthio}-1H-benzimidazole structure, CAS 117977-21-6

2-{[4(3-Methoxypropoxy)-3-methyl pyridine-2-yl]methylthio}-1H-benzimidazole

CAS Number117977-21-6

Synonyms2-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio]benzimidazole; MFCD08063845; 2-({[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl}sulfanyl)-1H-benzimidazole; 2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole; 2-({[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfanyl)-1H-benzimidazole; 2-[[[4-(3-Methoxy Propoxy)-3-methyl pyridine-2-yl]methyl ] thio]-1H-benzimidazole; 2-[[[4-(3-Methoxy Propoxy)-3-methyl pyridine-2-yl ]methyl ] thio]-1H-benzimidazole; 2-(((4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL)METHYL)THIO)-1H-BENZIMIDAZOLE; 2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfanyl]-1H-benzimidazole

Molecular FormulaC18H21N3O2S

Molecular Weight343.44

Purity98%

Density1.3±0.1 g/cm3

Boiling Point546.4±60.0 °C at 760 mmHg

Melting Point120.5-121.5ºC

Flash Point

AppearanceOff-white crystalline powder

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Cat. No.: 2A-9002192 Purity: 98%
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Quality Control of [ 117977-21-6 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number117977-21-6
Catalog No.2A-9002192
Chinese Name2-[[[4-(3-甲氧基丙氧基)-3-甲基嘧啶-2-基]甲基]硫代]-1H-苯并咪唑
Synonyms2-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio]benzimidazole; MFCD08063845; 2-({[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl}sulfanyl)-1H-benzimidazole; 2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole; 2-({[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfanyl)-1H-benzimidazole; 2-[[[4-(3-Methoxy Propoxy)-3-methyl pyridine-2-yl]methyl ] thio]-1H-benzimidazole; 2-[[[4-(3-Methoxy Propoxy)-3-methyl pyridine-2-yl ]methyl ] thio]-1H-benzimidazole; 2-(((4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL)METHYL)THIO)-1H-BENZIMIDAZOLE; 2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfanyl]-1H-benzimidazole
Molecular FormulaC18H21N3O2S
Molecular Weight343.44
Purity98
Density1.3±0.1 g/cm3
Boiling Point546.4±60.0 °C at 760 mmHg
Melting Point120.5-121.5ºC
AppearanceOff-white crystalline powder
Storage Condition-20°C Freezer
ApplicationRabeprazole Sulfide is the active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that inhibits gastric acid secretion by interacting with (H+/K+)-ATPase in gastric parietal cells. R
HTC2933990090
SMILESS(Cc3nccc(c3C)OCCCOC)c1[nH]c2c(n1)cccc2
InChI1S/C18H21N3O2S/c1-13-16(19-9-8-17(13)23-11-5-10-22-2)12-24-18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)
InChI KeyBSXAHDOWMOSVAP-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/2192_1_117977_21_6.pdf
BioactivityRabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H+/K+)-ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of H. pylori. Rabeprazole has the potential for various peptic diseases treatment[1][2]. Related Catalog Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Signaling Pathways >> Anti-infection >> Bacterial References [1]. Uno T, et al. Determination of rabeprazole and its active metabolite, rabeprazole thioether in human plasma by column-switching high-performance liquid chromatography and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):238-43. [2]. Tsutsui N, et al. A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori. Antimicrob Agents Chemother. 2000 Nov;44(11):3069-73. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 546.4±60.0 °C at 760 mmHg Melting Point 120.5-121.5ºC Molecular Formula C18H21N3O2S Molecular Weight 343.443 Flash Point 284.2±32.9 °C Exact Mass 343.135437 PSA 85.33000 LogP 3.53 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.636 InChIKey BSXAHDOWMOSVAP-UHFFFAOYSA-N SMILES COCCCOc1ccnc(CSc2nc3ccccc3[nH]2)c1C Storage condition -20°C Freezer
Use ofRabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H+/K+)-ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of H. pylori. Rabeprazole has the potential for various peptic diseases treatment[1][2]. Properties Name Rabeprazole Sulfide Synonym More Synonyms Rabeprazole thioether Biological Activity Description Rabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H+/K+)-ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of H. pylori. Rabeprazole has the potential for various peptic diseases treatment[1][2]. Related Catalog Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Signaling Pathways >> Anti-infection >> Bacterial References [1]. Uno T, et al. Determination of rabeprazole and its active metabolite, rabeprazole thioether in human plasma by column-switching high-performance liquid chromatography and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):238-43. [2]. Tsutsui N, et al. A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pylori. Antimicrob Agents Chemother. 2000 Nov;44(11):3069-73. Chemical & Physical Properties Molecular Formula C18H21N3O2S Exact Mass 343.135437 PSA 85.33000 Index of Refraction 1.636 InChIKey BSXAHDOWMOSVAP-UHFFFAOYSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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