CAS Number444-27-9
Synonyms(4R)-1,3-Thiazolidine-4-carboxylic acid; L-4-Thiazolidinecarboxylic acid; L-Thioproline; (R)-(-)-4-Thiazolidinecarboxylic acid; L- thiazolidine-4-carboxylic acid; MFCD00128958; EINECS 207-146-6; (4R)-4-Thiazolidinecarboxylic acid; (R)-Thiazolidine-4-carboxylic acid; 4-thiazolidinecarboxylic acid; 1-thiazolidine-4-carboxylic acid; L-Thiazolidine-4-carboxylic acid; Thiazolidine-4-carboxylic acid; Timonacic
Molecular FormulaC4H7O2N1S1
Molecular Weight133.17
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point350.3±37.0 °C at 760 mmHg
Melting Point199 - 201ºC
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 444-27-9 |
| Catalog No. | 2A-9021876 |
| Chinese Name | 噻莫西酸 |
| Synonyms | (4R)-1,3-Thiazolidine-4-carboxylic acid; L-4-Thiazolidinecarboxylic acid; L-Thioproline; (R)-(-)-4-Thiazolidinecarboxylic acid; L- thiazolidine-4-carboxylic acid; MFCD00128958; EINECS 207-146-6; (4R)-4-Thiazolidinecarboxylic acid; (R)-Thiazolidine-4-carboxylic acid; 4-thiazolidinecarboxylic acid; 1-thiazolidine-4-carboxylic acid; L-Thiazolidine-4-carboxylic acid; Thiazolidine-4-carboxylic acid; Timonacic |
| Molecular Formula | C4H7O2N1S1 |
| Molecular Weight | 133.17 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 350.3±37.0 °C at 760 mmHg |
| Melting Point | 199 - 201ºC |
| Storage Condition | Store airtight in a cool, dry place. |
| Packaging | III |
| Application | Timonacic is used as an adjuvant in the treatment of acute illnesses and liver disease. It is also used to treat some cancer cases by inducing reversal. |
| HTC | 2934999090 |
| MDL Number | MFCD00128958 |
| SMILES | O=C(O)C1CSCN1 |
| InChI Key | DZLNHFMRPBPULJ-UHFFFAOYSA-N |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/21876_1_444_27_9.pdf |
| Use of | Timonacic is used as an adjuvant in the treatment of acute and hepatic disorders. It has also been used for the treatment of some cases of cancer, through the induction of the reverse transformation. Properties Name thioproline Synonym More Synonyms Timonacic Biological Activity Description Timonacic is used as an adjuvant in the treatment of acute and hepatic disorders. It has also been used for the treatment of some cases of cancer, through the induction of the reverse transformation. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Research Areas >> Cardiovascular Disease References [1]. Bakry RS, et al. Spectrophotometric investigation of the formed chelate between timonacic and palladium(II) and its analytical applications. J Pharm Biomed Anal. 1998 May;17(1):95-101. Chemical & Physical Properties Molecular Formula C4H7NO2S Exact Mass 133.019745 PSA 74.63000 LogP -0.39 Index of Refraction 1.566 InChIKey DZLNHFMRPBPULJ-UHFFFAOYSA-N Storage condition 2-8℃ Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 4-Thiazolidinecarboxylic acid CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C4-H7-N-O2-S MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T5M CSTJ EVQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Kidney, Ureter, Bladder - renal function tests depressed REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,778,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Liver - other changes REFERENCE : DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,399,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Liver - other changes REFERENCE : DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,399,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GMITAB Gazzetta Medica Italiana. (Turin, Italy) V.95-142, 1936-83. Volume(issue)/page/year: 131,265,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,68,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,837,1980 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Endocrine - effect on menstrual cycle REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,453,1987 Safety Information RIDADR UN 2811 Packaging Group III Hazard Class 6.1(b) HS Code 2934999090 Synthetic Route Formaldehyde CAS#:50-00-0 D-Cysteine CAS#:921-01-7 CAS#:444-27-9 Literature: Shiraiwa, Tadashi; Kataoka, Kazuo; Sakata, Shinji; Kurokawa, Hidemoto Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 1 p. 109 - 113 Formaldehyde CAS#:50-00-0 L-Cysteine hydr... CAS#:52-89-1 CAS#:444-27-9 Literature: Padwa, Albert; Fryxell, Glen E.; Gasdaska, John R.; Venkatramanan, M. K.; Wong, George S. K. Journal of Organic Chemistry, 1989 , vol. 54, # 3 p. 644 - 653 Formaldehyde CAS#:50-00-0 CAS#:444-27-9 Literature: Neher; Wettstein; Miescher Helvetica Chimica Acta, 1946 , vol. 29, p. 1815,1824 Precursor & DownStream Precursor 4 CAS#:50-00-0 Formaldehyde CAS#:921-01-7 D-Cysteine CAS#:52-89-1 L-Cysteine hydr... CAS#:34592-47-7 L-Thioproline DownStream 10 CAS#:50703-06-5 4-Thiazolidinec... CAS#:51077-16-8 N-Boc-(R)-(-)-t... CAS#:5025-82-1 Folcisteine CAS#:1156496-63-7 4-carboxy-1,3-t... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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