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Trifluoperazine dihydrochloride structure, CAS 440-17-5

Trifluoperazine dihydrochloride

CAS Number440-17-5

SynonymsTrifluoperazine Dihydrochloride; 2-Trifluoromethyl-10-[3-(1-methyl-4-piperazinyl)propyl]phenothiazine dihydrochloride; 10H-Phenothiazine, 10-[3- (4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride; Phenothiazine, 10-[3- (4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride; 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine dihydrochloride; 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine,dihydrochloride; MFCD00012656; 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride; EINECS 207-123-0; 10H-phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride; 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, hydrochloride (

Molecular FormulaC21H26Cl2F3N3S

Molecular Weight480.42

Purity≥99%

Density

Boiling Point506ºC at 760 mmHg

Melting Point243 °C (dec.) (lit.)

Flash Point

Appearancepowder

EINECS207-123-0

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9021856 Purity: ≥99%
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Quality Control of [ 440-17-5 ] Purity: ≥99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number440-17-5
Catalog No.2A-9021856
Chinese Name盐酸三氟拉嗪
SynonymsTrifluoperazine Dihydrochloride; 2-Trifluoromethyl-10-[3-(1-methyl-4-piperazinyl)propyl]phenothiazine dihydrochloride; 10H-Phenothiazine, 10-[3- (4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride; Phenothiazine, 10-[3- (4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride; 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine dihydrochloride; 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine,dihydrochloride; MFCD00012656; 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride; EINECS 207-123-0; 10H-phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride; 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, hydrochloride (
Molecular FormulaC21H26Cl2F3N3S
Molecular Weight480.42
Purity≥99
Boiling Point506ºC at 760 mmHg
Melting Point243 °C (dec.) (lit.)
Appearancepowder
Water SolubilityWater solubility: completely soluble; insoluble: e
Storage Condition2-8°C
ApplicationTrifluoperazine dihydrochloride is a dopamine D2 receptor inhibitor with antipsychotic and antiemetic effects.
EINECS207-123-0
PubChem ID57654709
MDL NumberMFCD00012656
SMILESCl[H].Cl[H].CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1
InChI1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H
InChI KeyBXDAOUXDMHXPDI-UHFFFAOYSA-N
Beilstein/REAXYS3820024
NACRES CodeNA.77
UNSPSC12352200
Hazard SymbolsTransport
MSDSmsds/21856_1_440_17_5.pdf
BioactivityTrifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Target: Dopamine D2 ReceptorTrifluoperazine Dihydrochloride is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic. Trifluoperazine inhibited in a dose-dependent manner the stimulation of glycogenolysis, gluconeogenesis, and ureogenesis due to alpha 1-adrenergic stimulation in rat hepatocytes. Trifluoperazine is much more potent at alpha 1- than at alpha 2-adrenergic receptors [1]. Trifluoperazine was not clearly different in terms of 'no substantial improvement' (n=1016, 27 RCTs, RR 1.06 CI 0.98 to 1.14) or leaving the study early (n=930, 22 RCTs, RR 1.15 CI 0.83 to 1.58). Almost identical numbers of people reported at least one adverse event (60%) in each group (n=585, 14 RCTs, RR 0.99 CI 0.87 to 1.13), although trifluoperazine was more likely to cause extrapyramidal adverse effects overall when compared to low potency antipsychotics such as chlorpromazine (n=130, 3 RCTs, RR 1.66 CI 1.03 to 2.67, NNH 6 CI 3 to 121). One small study (n=38) found no clear differences between trifluoperazine and the atypical drug, sulpiride [2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [1]. Huerta-Bahena, J., R. Villalobos-Molina, and J.A. Garcia-Sainz, Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol, 1983. 23(1): p. 67-70. [2]. Marques, L.O., M.S. Lima, and B.G. Soares, Trifluoperazine for schizophrenia. Cochrane Database Syst Rev, 2004(1): p. CD003545. Chemical & Physical Properties Boiling Point 506ºC at 760 mmHg Melting Point 243 °C (dec.)(lit.) Molecular Formula C21H26Cl2F3N3S Molecular Weight 480.417 Flash Point 259.8ºC Exact Mass 479.117645 PSA 35.02000 LogP 6.49040 Vapour Pressure 2.32E-10mmHg at 25°C InChIKey BXDAOUXDMHXPDI-UHFFFAOYSA-N SMILES CN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1.Cl.Cl Storage condition 2-8°C Stability Hygroscopic
Use ofProperties Articles13 Name trifluoperazine hydrochloride Synonym More Synonyms Trifluoperazine dihydrochloride Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease References [1]. Huerta-Bahena, J., R. Villalobos-Molina, and J.A. Garcia-Sainz, Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol, 1983. 23(1): p. 67-70. [2]. Marques, L.O., M.S. Lima, and B.G. Soares, Trifluoperazine for schizophrenia. Cochrane Database Syst Rev, 2004(1): p. CD003545. Chemical & Physical Properties Exact Mass 479.117645 PSA 35.02000 LogP 6.49040 InChIKey BXDAOUXDMHXPDI-UHFFFAOYSA-N Stability Hygroscopic
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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