CAS Number396-01-0
SynonymsTriamterene; MFCD00006708; 6-Phenylpteridine-2,4,7-triamine; 2,4,7-Triamino-6-phenylpteridine,6-Phenyl-2,4,7-pteridinetriamine; EINECS 206-904-3; 2,4,7-Triamino-6-phenylpteridine 6-Phenyl-2,4,7-pteridinetriamine
Molecular FormulaC12H11N7
Molecular Weight254.25
Purity98.00%
Density1.502 g/cm3
Boiling Point573.4ºC at 760 mmHg
Melting Point316°C
Appearanceyellow solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 396-01-0 |
| Catalog No. | 2A-9021679 |
| Chinese Name | 氨苯蝶啶 |
| Synonyms | Triamterene; MFCD00006708; 6-Phenylpteridine-2,4,7-triamine; 2,4,7-Triamino-6-phenylpteridine,6-Phenyl-2,4,7-pteridinetriamine; EINECS 206-904-3; 2,4,7-Triamino-6-phenylpteridine 6-Phenyl-2,4,7-pteridinetriamine |
| Molecular Formula | C12H11N7 |
| Molecular Weight | 254.25 |
| Purity | 98.00 |
| Density | 1.502 g/cm3 |
| Boiling Point | 573.4ºC at 760 mmHg |
| Melting Point | 316°C |
| Appearance | yellow solid |
| Water Solubility | <0.1 G/100 ML AT 20 ºC |
| Storage Condition | 2-8°C |
| Packaging | III |
| Application | Triamterene is a pressure-sensitive epithelial sodium channel (ENaC) blocker with diuretic effects. |
| HTC | 2933990090 |
| SMILES | [nH]1c2nc(n[c](c2nc(c1N)c3ccccc3)=O)N |
| InChI | 1S/C12H10N6O/c13-9-7(6-4-2-1-3-5-6)15-8-10(16-9)17-12(14)18-11(8)19/h1-5H,(H5,13,14,16,17,18,19) |
| InChI Key | UDZYJMZMGMKNJZ-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/21679_1_396_01_0.pdf |
| Bioactivity | Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.Target: Sodium ChannelTriamterene blocked rENaC in a voltage-dependent manner, and was 100-fold less potent than amiloride at pH 7.5. At -90 mV and -40 mV, the IC50 values were 5 microM and 10 microM, respectively. The blockage by triamterene, which is a weak base with a pKa of 6.2, was dependent on the extracellular pH. The IC50 was 1 microM at pH 6.5 and only 17 microM at pH 8.5 [1]. Triamterene (TA) is partly eliminated by a first-pass-effect. The main metabolite of TA is OH-TA-ester, which is pharmacologically active [2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Metabolic Disease References [1]. Busch, A.E., et al., Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis. Pflugers Arch, 1996. 432(5): p. 760-6. [2]. Gilfrich, H.J., et al., Pharmacokinetics of triamterene after i.v. administration to man: determination of bioavailability. Eur J Clin Pharmacol, 1983. 25(2): p. 237-41. Chemical & Physical Properties Density 1.502 g/cm3 Boiling Point 573.4ºC at 760 mmHg Melting Point 316°C Molecular Formula C12H11N7 Molecular Weight 253.26300 Flash Point 11 °C Exact Mass 253.10800 PSA 129.62000 LogP 2.57700 InChIKey FNYLWPVRPXGIIP-UHFFFAOYSA-N SMILES Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1 Storage condition 2-8°C Water Solubility <0.1 G/100 ML AT 20 ºC |
| Use of | Properties Articles33 Name 2,4,7-Triamino-6-Phenylpteridine Synonym More Synonyms Triamterene Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Metabolic Disease References [1]. Busch, A.E., et al., Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis. Pflugers Arch, 1996. 432(5): p. 760-6. [2]. Gilfrich, H.J., et al., Pharmacokinetics of triamterene after i.v. administration to man: determination of bioavailability. Eur J Clin Pharmacol, 1983. 25(2): p. 237-41. Chemical & Physical Properties Molecular Formula C12H11N7 Exact Mass 253.10800 PSA 129.62000 LogP 2.57700 InChIKey FNYLWPVRPXGIIP-UHFFFAOYSA-N Water Solubility <0.1 G/100 ML AT 20 ºC |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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