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Sodium cholate structure, CAS 361-09-1

Sodium cholate

CAS Number361-09-1

Synonymscolalin; cholic acid sodium; cholsaeure; sodium salt of cholic acid; Cholic acid,sodium salt; EINECS 206-643-5; 7,12-Triol; Cholic acid; CHOLALIC ACID; SodiumCholate; CHOLIC ACID NA-SALT; 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt,Cholalic acid sodium salt; deoxycholic acid sodium salt; MFCD00064138; SODIUMCHOLATE,REAGENT; SODIUM CHOLEATE; Sodium cholate; CHOLIC ACID SODIUM SALT

Molecular FormulaC24H40NaO5

Molecular Weight430.55

Purity>96 (TLC)%

Density

Boiling Point583.9ºC at 760 mmHg

Melting Point198ºC

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9021499 Purity: >96 (TLC)%
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Quality Control of [ 361-09-1 ] Purity: >96 (TLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number361-09-1
Catalog No.2A-9021499
Chinese Name胆酸钠
Synonymscolalin; cholic acid sodium; cholsaeure; sodium salt of cholic acid; Cholic acid,sodium salt; EINECS 206-643-5; 7,12-Triol; Cholic acid; CHOLALIC ACID; SodiumCholate; CHOLIC ACID NA-SALT; 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt,Cholalic acid sodium salt; deoxycholic acid sodium salt; MFCD00064138; SODIUMCHOLATE,REAGENT; SODIUM CHOLEATE; Sodium cholate; CHOLIC ACID SODIUM SALT
Molecular FormulaC24H40NaO5
Molecular Weight430.55
Purity>96 (TLC)
Boiling Point583.9ºC at 760 mmHg
Melting Point198ºC
Appearancesolid
Water Solubility150 g/L (20 ºC)
Storage ConditionSealed packaging in brown glass bottles. Store at
ApplicationCholic acid sodium is the primary bile acid produced in the liver, often conjugated with glycine or taurine, and aids in fat absorption and cholesterol excretion.
MDL NumberMFCD00077281
SMILES[Na+].[O-]C(=O)CC[C@H]([C@@H]1[C@@]2([C@H]([C@H]3[C@@H]([C@@]4([C@H](C[C@H]3O)C[C@@H](CC4)O)C)C[C@@H]2O)CC1)C)C
InChI1S/C24H40O5.Na/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);/q;+1/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;/m1./s1
InChI KeyNRHMKIHPTBHXPF-TUJRSCDTSA-M
NACRES CodeNA.25
UNSPSC12352106
MSDSmsds/21499_1_361_09_1.pdf
BioactivityCholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Related Catalog Research Areas >> Metabolic Disease In Vitro Cholic acid competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway[1]. Cell Assay HepG2 cells are pretreated with the inhibitors NaN3 (1 mg/mL), Genistein (50 μg/mL), MβCD (10 mM), Nystatin (50 μg/mL), Chlorpromazine (10 μg/mL), and Cholic acid (1 mg/mL) for 30 min. After removing the inhibitors, the cells are incubated with CA-LPs for 2 h, and the cellular uptake of LPs is determined in the "In vitro cellular uptake assays" section[1]. References [1]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684. [2]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45(4):346-352. Chemical & Physical Properties Boiling Point 583.9ºC at 760 mmHg Melting Point 198ºC Molecular Formula C24H40NaO5 Molecular Weight 430.553 Flash Point 321ºC Exact Mass 430.269531 PSA 100.82000 LogP 2.11400 Index of Refraction 35 ° (C=0.6, EtOH) InChIKey NRHMKIHPTBHXPF-TUJRSCDTSA-M SMILES CC(CCC(=O)[O-])C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.[Na+] Water Solubility 150 g/L (20 ºC)
Use ofCholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Properties Name sodium cholate Synonym More Synonyms sodium cholate Biological Activity Description Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Related Catalog Research Areas >> Metabolic Disease References [1]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684. [2]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45(4):346-352. Chemical & Physical Properties Molecular Formula C24H40NaO5 Exact Mass 430.269531 PSA 100.82000 LogP 2.11400 InChIKey NRHMKIHPTBHXPF-TUJRSCDTSA-M
Transport InfoProduct Name: Sodium Cholate
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