CAS Number298-93-1
Synonyms3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium Bromide; ThiazolylBlue(Mtt); MttA.R.; 2H-Tetrazolium, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-, bromide (1:1); 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium Bromide; 3-(4,5-Dimethyl-1,3-thiazol-2-yl)-2,5-diphenyl-2H-tetrazol-3-ium bromide; Methylthiazoletetrazolium bromide; Thiazolyl Blue; 2H-tetrazolium, 2-(4,5-dimethyl-2-thiazolyl)-3,5-diphenyl-, bromide (1:1); 2-(4,5-Dimethyl-1,3-thiazol-2-yl)-3,5-diphenyl-2H-tetrazol-3-ium bromide; MFCD00011964; EINECS 206-069-5; THIAZOLE BLUE; Thiazolyl blue tetrazolium bromide (MTT); thiazolyl blue tetrazolium bromide; mmttetrazolium; 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyl-2H-Tetrazolium Bromide; MTT
Molecular FormulaC18H16BrN5S
Molecular Weight414.32
Purity98%
Melting Point195 °C (dec.) (lit.)
Appearancepowder
EINECS206-069-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 298-93-1 |
| Catalog No. | 2A-9021144 |
| Chinese Name | 噻唑兰 |
| Synonyms | 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium Bromide; ThiazolylBlue(Mtt); MttA.R.; 2H-Tetrazolium, 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-, bromide (1:1); 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium Bromide; 3-(4,5-Dimethyl-1,3-thiazol-2-yl)-2,5-diphenyl-2H-tetrazol-3-ium bromide; Methylthiazoletetrazolium bromide; Thiazolyl Blue; 2H-tetrazolium, 2-(4,5-dimethyl-2-thiazolyl)-3,5-diphenyl-, bromide (1:1); 2-(4,5-Dimethyl-1,3-thiazol-2-yl)-3,5-diphenyl-2H-tetrazol-3-ium bromide; MFCD00011964; EINECS 206-069-5; THIAZOLE BLUE; Thiazolyl blue tetrazolium bromide (MTT); thiazolyl blue tetrazolium bromide; mmttetrazolium; 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyl-2H-Tetrazolium Bromide; MTT |
| Molecular Formula | C18H16BrN5S |
| Molecular Weight | 414.32 |
| Purity | 98 |
| Melting Point | 195 °C (dec.) (lit.) |
| Appearance | powder |
| Water Solubility | Slightly soluble |
| Storage Condition | Store at 2-8℃. |
| Application | MTT is a colorimetric agent widely used to measure cell proliferation. MTT reduces the color from yellow to purple in living cells. |
| EINECS | 206-069-5 |
| HTC | 29341000 |
| PubChem ID | 24896603 |
| MDL Number | MFCD00011964 |
| SMILES | [Br-].Cc1nc(sc1C)-[n+]2nc(nn2-c3ccccc3)-c4ccccc4 |
| InChI | 1S/C18H16N5S.BrH/c1-13-14(2)24-18(19-13)23-21-17(15-9-5-3-6-10-15)20-22(23)16-11-7-4-8-12-16;/h3-12H,1-2H3;1H/q+1;/p-1 |
| InChI Key | AZKSAVLVSZKNRD-UHFFFAOYSA-M |
| Beilstein/REAXYS | 4081397 |
| NACRES Code | NA.47 |
| UNSPSC | 12352111 |
| Hazard Symbols | Transport |
| MSDS | msds/21144_1_298_93_1.pdf |
| Bioactivity | MTT is a colorimetric agent widely used to measure cell proliferation. MTT is reduced from yellow color to purple formazan in living cells. Related Catalog Signaling Pathways >> Others >> Others Biochemical Assay Reagents Research Areas >> Others In Vitro MTT is used in conjunction with rhodamine B to measure mitochondrial membrane potential. MTT-formazan is generated in mitochondria acts as a fluorescence quencher for rhodamine that distributes across membranes of viable cells according to membrane potential. In the absence of mPMS, cellular reduction of MTT is strong. MTT is membrane-impermeable when incorporated into large unilamellar liposomes, and therefore it is taken up by cells via endocytosis[1]. References [1]. Berridge MV, et al. Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Annu Rev. 2005;11:127-52. Chemical & Physical Properties Melting Point 195 °C (dec.)(lit.) Molecular Formula C18H16BrN5S Molecular Weight 414.322 Exact Mass 413.030975 PSA 75.72000 LogP 0.28830 InChIKey AZKSAVLVSZKNRD-UHFFFAOYSA-M SMILES Cc1nc(-[n+]2nc(-c3ccccc3)nn2-c2ccccc2)sc1C.[Br-] Storage condition 2-8°C Water Solubility Slightly soluble |
| Use of | MTT is a colorimetric agent widely used to measure cell proliferation. MTT is reduced from yellow color to purple formazan in living cells. Properties Articles3106 Name 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Synonym More Synonyms Thiazolyl Blue Biological Activity Description MTT is a colorimetric agent widely used to measure cell proliferation. MTT is reduced from yellow color to purple formazan in living cells. Related Catalog Signaling Pathways >> Others >> Others Biochemical Assay Reagents Research Areas >> Others In Vitro MTT is used in conjunction with rhodamine B to measure mitochondrial membrane potential. MTT-formazan is generated in mitochondria acts as a fluorescence quencher for rhodamine that distributes across membranes of viable cells according to membrane potential. In the absence of mPMS, cellular reduction of MTT is strong. MTT is membrane-impermeable when incorporated into large unilamellar liposomes, and therefore it is taken up by cells via endocytosis[1]. References [1]. Berridge MV, et al. Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Annu Rev. 2005;11:127-52. Chemical & Physical Properties Molecular Formula C18H16BrN5S Exact Mass 413.030975 PSA 75.72000 LogP 0.28830 InChIKey AZKSAVLVSZKNRD-UHFFFAOYSA-M Water Solubility Slightly soluble |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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