CAS Number142-47-2
SynonymsMSG; MFCD00013074; Glutamate monosodium salt; L-GLUTAMIC ACID SODIUM SALT; monosodium-l-glutamate; Sodium (2S)-2-ammoniopentanedioate; L-(+)Sodium Glutamate; L-Glutamic acid monosodium salt; (S)-2-Aminopentanedioic acid,L-Glutamic acid monosodium salt,Glu; L-Sodium glutamate hydrate; Monosodium glutamate; sodium L-glutamate; EINECS 205-538-1; L-Glutamic acid, sodium salt; L-Glutamic acid monosodium salt hydrate; Glutamic acid sodium salt; sodium glutamate; Glutamic acid, monosodium salt; L-Glutamic acid, monosodium salt; L-Glutamic acid, sodium salt (1:1)
Molecular FormulaC5H8NNaO4
Molecular Weight169.11 (anhydrous basis)
Purity≥99 (HPLC)%
Boiling Point333.8ºC at 760 mmHg
Melting Point232°C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 142-47-2 |
| Catalog No. | 2A-9020909 |
| Chinese Name | 谷氨酸钠 |
| Synonyms | MSG; MFCD00013074; Glutamate monosodium salt; L-GLUTAMIC ACID SODIUM SALT; monosodium-l-glutamate; Sodium (2S)-2-ammoniopentanedioate; L-(+)Sodium Glutamate; L-Glutamic acid monosodium salt; (S)-2-Aminopentanedioic acid,L-Glutamic acid monosodium salt,Glu; L-Sodium glutamate hydrate; Monosodium glutamate; sodium L-glutamate; EINECS 205-538-1; L-Glutamic acid, sodium salt; L-Glutamic acid monosodium salt hydrate; Glutamic acid sodium salt; sodium glutamate; Glutamic acid, monosodium salt; L-Glutamic acid, monosodium salt; L-Glutamic acid, sodium salt (1:1) |
| Molecular Formula | C5H8NNaO4 |
| Molecular Weight | 169.11 (anhydrous basis) |
| Purity | ≥99 (HPLC) |
| Boiling Point | 333.8ºC at 760 mmHg |
| Melting Point | 232°C |
| Appearance | powder |
| Water Solubility | ≥10 g/100 mL at 20 ºC |
| Storage Condition | 1. Store sealed in a dry and cool place. 2. Do not |
| Application | L-Glutamic acid monosodium salt (Monosodium glutamate) is an mGlu1 receptor activator. |
| HTC | 2922422000 |
| PubChem ID | 24895069 |
| MDL Number | MFCD00013074 |
| SMILES | [NaH].NC(CCC(=O)O)C(=O)O.O |
| InChI | 1S/C5H9NO4.Na.H2O.H/c6-3(5(9)10)1-2-4(7)8;;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2; |
| InChI Key | JYDGDQPVBSBYRT-UHFFFAOYSA-N |
| NACRES Code | NA.32 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| MSDS | msds/20909_1_142_47_2.pdf |
| Bioactivity | L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor. Related Catalog Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease Target mGlu1 receptor[1] In Vivo A single systemic injection of L-Glutamic acid monosodium salt (MSG) (3 g/kg) to PND9 mice causes extensive retinal degeneration and reduces the number of Brn-3a+RGCs by >70% with respect to control mice treated with saline; In mice treated with L-Glutamic acid monosodium salt and JNJ16259685, the number of RGC is reduced by only <20%, and the resulting value is not significantly different from values obtained in all other groups of mice, including control mice. L-Glutamic acid monosodium salt administration to wild-type BALB/c littermates reduces RGC number to a lower extent than in C57BL/6J mice, but the reduction is still highly significant[1]. Animal Admin For toxicity experiments, mice at PND9 (n=3-9 mice per group) are treated as follows. Two groups receive a subcutaneous (s.c.) injection of corn oil, following, 30 min later, by s.c. injection of either saline or L-Glutamic acid monosodium salt (3 g/kg); two additional groups are treated with 3,4-dihydro-2 H-pyrano[2,3-b]quinolin-7-yl-(cis-4-methoxycyclohexyl)-methanone, dissolving in corn oil (2.5 mg/kg) following, 30 min later, by a s.c. injection of either saline or L-Glutamic acid monosodium salt. In another set of experiments, four groups of crv4 mice or their wild-type littermates (n=5-7 mice per group) are injected s.c. with either saline or L-Glutamic acid monosodium salt (3 g/kg)[1]. References [1]. Liberatore F, et al. Permissive role for mglu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Sep 14. pii: S0306-4522(17)30640-1. Chemical & Physical Properties Boiling Point 333.8ºC at 760 mmHg Melting Point 232°C Molecular Formula C5H8NNaO4 Molecular Weight 169.111 Flash Point 155.7ºC Exact Mass 169.035110 PSA 103.45000 Vapour Pressure 2.55E-05mmHg at 25°C Index of Refraction 25 ° (C=10, 2mol/L HCl) InChIKey LPUQAYUQRXPFSQ-DFWYDOINSA-M SMILES NC(CCC(=O)[O-])C(=O)O.[Na+] Water Solubility ≥10 g/100 mL at 20 ºC |
| Use of | L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor. Properties Name monosodium L-glutamate Synonym More Synonyms L-(+)Sodium glutamate Biological Activity Description L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor. Related Catalog Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease mGlu1 receptor[1] References Chemical & Physical Properties Molecular Formula C5H8NNaO4 Exact Mass 169.035110 PSA 103.45000 InChIKey LPUQAYUQRXPFSQ-DFWYDOINSA-M SMILES NC(CCC(=O)[O-])C(=O)O.[Na+] |
| Tax Rebate | 9.0% |
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| Inspection | P. Quarantine of entry animals, plants, and animal and plant products Q. Quarantine of exit animals, plants, and animal and plant products R. Hygiene supervision and inspection of imported food S. Hyg |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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