CAS Number141-90-2
Synonyms2-Thioxo-1,2,3,4-tetrahydropyrimidin-4-one; tiouracyl; TU; 2-Thiouracil; 2,3-dihydro-2-thioxo-(1H)pyrimidin-4-one; 2-Mercapto-4-pyrimidone; 2-Sulfanylpyrimidin-4(3H)-one; THIURACIL; 2-Thioxo-2,3-dihydro-4(1H)-pyrimidinone; 2-TU; Nobilen; Thiouracil; 2-Mercapto-4-hydroxypyrimidine; 2-Thioxo-2,3-dihydropyrimidin-4(1H)-one; 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine; EINECS 205-508-8; Thiouraci; MFCD00006039; DERACIL; 2-sulfanylpyrimidin-4-ol
Molecular FormulaC4H4N2OS
Molecular Weight128.15
Purity≥99%
Density1.5±0.1 g/cm3
Boiling Point337.2ºC at 760mmHg
Melting Point>300 °C (lit.)
Appearancepowder
EINECS205-508-8
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 141-90-2 |
| Catalog No. | 2A-9020886 |
| Chinese Name | 2-硫脲嘧啶 |
| Synonyms | 2-Thioxo-1,2,3,4-tetrahydropyrimidin-4-one; tiouracyl; TU; 2-Thiouracil; 2,3-dihydro-2-thioxo-(1H)pyrimidin-4-one; 2-Mercapto-4-pyrimidone; 2-Sulfanylpyrimidin-4(3H)-one; THIURACIL; 2-Thioxo-2,3-dihydro-4(1H)-pyrimidinone; 2-TU; Nobilen; Thiouracil; 2-Mercapto-4-hydroxypyrimidine; 2-Thioxo-2,3-dihydropyrimidin-4(1H)-one; 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine; EINECS 205-508-8; Thiouraci; MFCD00006039; DERACIL; 2-sulfanylpyrimidin-4-ol |
| Molecular Formula | C4H4N2OS |
| Molecular Weight | 128.15 |
| Purity | ≥99 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 337.2ºC at 760mmHg |
| Melting Point | >300 °C (lit.) |
| Appearance | powder |
| Water Solubility | 0.5 g/L |
| Storage Condition | Store sealed and away from light. |
| Packaging | III |
| Application | 2-Thouracil is a thiolate uracil derivative that has anti-hyperthyroidism effects. |
| EINECS | 205-508-8 |
| HTC | 29335995 |
| PubChem ID | 24900470 |
| MDL Number | MFCD00006039 |
| SMILES | O=C1NC(=S)NC=C1 |
| InChI | 1S/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) |
| InChI Key | ZEMGGZBWXRYJHK-UHFFFAOYSA-N |
| Beilstein/REAXYS | 112227 |
| NACRES Code | NA.51 |
| UNSPSC | 41106305 |
| Hazard Symbols | Category 9 |
| MSDS | msds/20886_1_141_90_2.pdf |
| Bioactivity | 2-Thiouracil is a thiolated uracil derivative that is a known antihyperthyroid agent. Target: Others2-Thiouracil is an established antithyroid drug and an extensively investigated agent for the early detection and targeting of metastatic melanotic melanoma. In addition, 2-Thiouracil is also a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerization. Thiouracil refers both to a specific molecule consisting of a sulfated uracil, and a family of molecules based upon that structure. Thiouracil inhibits thyroid activity by blocking the enzyme thyroid peroxidase [1-3]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Endocrinology References [1]. Palumbo, A., M. d'Ischia, and F.A. Cioffi, 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485(2-3): p. 109-12. [2]. Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39(26): p. 5192-201. [3]. Nagasaka, A. and H. Hidaka, Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase. J Clin Endocrinol Metab, 1976. 43(1): p. 152-8. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 337.2ºC at 760mmHg Melting Point >300 °C(lit.) Molecular Formula C4H4N2OS Molecular Weight 128.152 Flash Point 157.7ºC Exact Mass 128.004440 PSA 80.74000 LogP -0.28 Vapour Pressure 5.45E-05mmHg at 25°C Index of Refraction 1.678 InChIKey ZEMGGZBWXRYJHK-UHFFFAOYSA-N SMILES O=c1cc[nH]c(=S)[nH]1 Storage condition 2-8°C Water Solubility 0.5 g/L |
| Use of | Properties Articles34 Name thiouracil Synonym More Synonyms 2-Thiouracil Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Endocrinology References [1]. Palumbo, A., M. d'Ischia, and F.A. Cioffi, 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485(2-3): p. 109-12. [2]. Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39(26): p. 5192-201. [3]. Nagasaka, A. and H. Hidaka, Effect of antithyroid agents 6-propyl-2-thiouracil and 1-mehtyl-2-mercaptoimidazole on human thyroid iodine peroxidase. J Clin Endocrinol Metab, 1976. 43(1): p. 152-8. Chemical & Physical Properties Molecular Formula C4H4N2OS Exact Mass 128.004440 PSA 80.74000 LogP -0.28 Index of Refraction 1.678 InChIKey ZEMGGZBWXRYJHK-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: Category 9 Miscellaneous UN number: 3077 Proper shipping name: Environmentally Hazardous Substance, Solid, Not otherwise specified Packing grade: III Marine pollutants: Y |
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