CAS Number134-58-7
Synonyms2-Amino-6-hydroxy-8-azapurine,2-Amino-6-oxy-8-azapurine,8-AzaG; EINECS 205-148-1; 8-Azaguanine; MFCD00056937; 5-imino-3,4,5,6-tetrahydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one; 5-amino-2,3-dihydrotriazolo[4,5-d]pyrimidin-7-one; 5-Amino-1H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one; 5-Amino-1,4-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
Molecular FormulaC4H4N6O
Molecular Weight152.11
Purity≥98 (HPLC)%
Density2.6±0.1 g/cm3
Melting Point>300 °C (lit.)
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 134-58-7 |
| Catalog No. | 2A-9020729 |
| Chinese Name | 8-氮鸟嘌呤 |
| Synonyms | 2-Amino-6-hydroxy-8-azapurine,2-Amino-6-oxy-8-azapurine,8-AzaG; EINECS 205-148-1; 8-Azaguanine; MFCD00056937; 5-imino-3,4,5,6-tetrahydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one; 5-amino-2,3-dihydrotriazolo[4,5-d]pyrimidin-7-one; 5-Amino-1H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one; 5-Amino-1,4-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one |
| Molecular Formula | C4H4N6O |
| Molecular Weight | 152.11 |
| Purity | ≥98 (HPLC) |
| Density | 2.6±0.1 g/cm3 |
| Melting Point | >300 °C (lit.) |
| Appearance | powder |
| Storage Condition | Keep sealed. |
| Application | 8-Azaguanine is a purine analog showing antitumor activity. |
| HTC | 2933990090 |
| MDL Number | MFCD00056937 |
| SMILES | NC1=Nc2[nH]nnc2C(=O)N1 |
| InChI | 1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11) |
| InChI Key | LPXQRXLUHJKZIE-UHFFFAOYSA-N |
| Beilstein/REAXYS | 171098 |
| NACRES Code | NA.21 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/20729_1_134_58_7.pdf |
| Bioactivity | 8-Azaguanine is a purine analogue which shows antineoplastic activity. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Cancer In Vitro 8-Azaguanine is a purine analogue which shows antineoplastic activity. The results show that cell viability decreases after incubation with 8-Azaguanine, in a dose and time dependent manner. After 24 h of treatment with 8-Azaguanine the IC50 for CEM cell line is about 100 μM while for MOLT3 cell line the IC50 is about 10 μM. CEM and MOLT3 cells surface expression of CD26 increases after treatment with 8-Azaguanine in a concentrations dependent manner[1]. Cell Assay Detection of apoptosis and necrosis is analyzed by Annexin V and propidium iodide staining. After incubation in the absence or in the presence of 8-Azaguanine, cells are washed (centrifuged at 300×g during 5 min) and incubated for 10 min at 4°C in 440 μL Annexin buffer, containing 5 μL Annexin V and 5 μL propidium iodide. Then cells are washed and re-suspended in phosphate buffered saline (PBS) until analysis[1]. References [1]. Dourado M, et al. CD26/DPPIV expression and 8-azaguanine response in T-acute lymphoblastic leukaemia cell lines in culture. Pathophysiology. 2007 May;14(1):3-10. Chemical & Physical Properties Density 2.6±0.1 g/cm3 Melting Point >300 °C(lit.) Molecular Formula C4H4N6O Molecular Weight 152.114 Flash Point 129.1ºC Exact Mass 152.044662 PSA 113.34000 LogP -0.71 Vapour Pressure 0.00149mmHg at 25°C Index of Refraction 2.308 |
| Use of | 8-Azaguanine is a purine analogue which shows antineoplastic activity. Properties Articles29 Name 8-azaguanine Synonym More Synonyms 8-Azaguanine Biological Activity Description 8-Azaguanine is a purine analogue which shows antineoplastic activity. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Cancer References Chemical & Physical Properties Molecular Formula C4H4N6O Exact Mass 152.044662 PSA 113.34000 LogP -0.71 Index of Refraction 2.308 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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