CAS Number127-79-7
Synonyms2-sulfanilamido-4-methylpyrimidine; Mesulfa; 4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide (N1-(4-Methylpyrimidin-2-yl)sulfanilamide; Mebacid; 4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide; SMI; A-310; METSULFA; Romezin; sulfamerazine; Sulfamerazin; RP 2632; 4-amino-N-(4-methylpyrimidin-2-yl)benzenesulfonamide; sulphamerazine; 2643-RP; EINECS 204-866-2; DEBENAL; MFCD00023212
Molecular FormulaC11H12N4O2S
Molecular Weight264.30
Purity≥99.0%
Density1.4±0.1 g/cm3
Boiling Point519.1±52.0 °C at 760 mmHg
Melting Point234-238°C
AppearanceWhite or light yellow crystalline powder
EINECS204-866-2
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 127-79-7 |
| Catalog No. | 2A-9020594 |
| Chinese Name | 磺胺甲基嘧啶 |
| Synonyms | 2-sulfanilamido-4-methylpyrimidine; Mesulfa; 4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide (N1-(4-Methylpyrimidin-2-yl)sulfanilamide; Mebacid; 4-Amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide; SMI; A-310; METSULFA; Romezin; sulfamerazine; Sulfamerazin; RP 2632; 4-amino-N-(4-methylpyrimidin-2-yl)benzenesulfonamide; sulphamerazine; 2643-RP; EINECS 204-866-2; DEBENAL; MFCD00023212 |
| Molecular Formula | C11H12N4O2S |
| Molecular Weight | 264.30 |
| Purity | ≥99.0 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 519.1±52.0 °C at 760 mmHg |
| Melting Point | 234-238°C |
| Appearance | White or light yellow crystalline powder |
| Storage Condition | Warehouse Ventilation Low Temperature Drying |
| Application | Sulfamerazine (RP-2632) is a sulfonamide antibiotic. |
| EINECS | 204-866-2 |
| HTC | 2935009090 |
| PubChem ID | 57654637 |
| MDL Number | MFCD00023212 |
| SMILES | Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1 |
| InChI | 1S/C11H12N4O2S/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15) |
| InChI Key | QPPBRPIAZZHUNT-UHFFFAOYSA-N |
| Beilstein/REAXYS | 249133 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/20594_1_127_79_7.pdf |
| Bioactivity | Sulfamerazine(RP-2632) is a sulfonamide antibacterial.Target: AntibacterialSulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sulfamerazine is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA [1]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. HALL, W.H. and W.W. SPINK, Sulfamerazine: clinical evaluation in 116 cases. Journal of the American Medical Association, 1943. 123(3): p. 125-131. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 519.1±52.0 °C at 760 mmHg Melting Point 234-238°C Molecular Formula C11H12N4O2S Molecular Weight 264.304 Flash Point 267.8±30.7 °C Exact Mass 264.068085 PSA 106.35000 LogP 0.34 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.660 InChIKey QPPBRPIAZZHUNT-UHFFFAOYSA-N SMILES Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1 |
| Use of | Sulfamerazine(RP-2632) is a sulfonamide antibacterial.Target: AntibacterialSulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sulfamerazine is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA [1]. Properties Articles49 Name sulfamerazine Synonym More Synonyms Sulfamerazine Biological Activity Description Sulfamerazine(RP-2632) is a sulfonamide antibacterial.Target: AntibacterialSulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sulfamerazine is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA [1]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References Chemical & Physical Properties Molecular Formula C11H12N4O2S Exact Mass 264.068085 PSA 106.35000 Index of Refraction 1.660 InChIKey QPPBRPIAZZHUNT-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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