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Sulfisoxazole structure, CAS 127-69-5

Sulfisoxazole

CAS Number127-69-5

Synonyms4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide; 4-Amino-N-(3,4-dimethylisoxazol-5-yl)-benzenesulfonamide; 4-Amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide; Gantrizin; Sulfisoxazole; T5NOJ CMSWR DZ& D1 E1; N1-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide; Sulfafurazole; EINECS 204-858-9; MFCD00003150; 4-Amino-N-(3,4-d; 5-(p-Aminobenzenesulfonamido)-3,4-dimethylisooxazole; 4-Amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide

Molecular FormulaC11H13N3O3S

Molecular Weight267.30

Purity98.00%

Density1.4±0.1 g/cm3

Boiling Point482.2±55.0 °C at 760 mmHg

Melting Point195°C

Flash Point

AppearanceWhite to cream powder

EINECS204-858-9

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9020591 Purity: 98.00%
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Quality Control of [ 127-69-5 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number127-69-5
Catalog No.2A-9020591
Chinese Name磺胺二甲异唑
Synonyms4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide; 4-Amino-N-(3,4-dimethylisoxazol-5-yl)-benzenesulfonamide; 4-Amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide; Gantrizin; Sulfisoxazole; T5NOJ CMSWR DZ& D1 E1; N1-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide; Sulfafurazole; EINECS 204-858-9; MFCD00003150; 4-Amino-N-(3,4-d; 5-(p-Aminobenzenesulfonamido)-3,4-dimethylisooxazole; 4-Amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide
Molecular FormulaC11H13N3O3S
Molecular Weight267.30
Purity98.00
Density1.4±0.1 g/cm3
Boiling Point482.2±55.0 °C at 760 mmHg
Melting Point195°C
AppearanceWhite to cream powder
Water Solubility<0.1 g/100 mL at 22.5 ºC
Storage Condition2-8°C
ApplicationSulfisoxazole is an endothelin receptor antagonist and a sulfa antibiotic.
EINECS204-858-9
HTC2935009090
PubChem ID329753912
MDL NumberMFCD00003150
SMILESCc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C
InChI1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3
InChI KeyNHUHCSRWZMLRLA-UHFFFAOYSA-N
Beilstein/REAXYS6737262
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/20591_1_127_69_5.pdf
BioactivitySulfisoxazole, an endothelin receptor antagonist, is a sulfonamide antibacterial with an oxazole substituent.Target: Antibacterial; Endothelin ReceptorThe sulfanilamide antibacterial agent sulfisoxazole was found to be a good endothelin receptor antagonist (IC50's of 0.60 microM and 22 microM for the ETA and ETB receptors, respectively) [1]. Sulfisoxazole is used to treat or prevent infections in many different parts of the body. It belongs to the group of medicines known as sulfonamide antibiotics. It works by preventing the growth of bacteria [2]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Research Areas >> Infection References [1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34. [2]. http://www.mayoclinic.org/drugs-supplements/sulfisoxazole-oral-route/description/drg-20072998 Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 482.2±55.0 °C at 760 mmHg Melting Point 195°C Molecular Formula C11H13N3O3S Molecular Weight 267.304 Flash Point 245.4±31.5 °C Exact Mass 267.067749 PSA 106.60000 LogP 1.01 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.626 InChIKey NHUHCSRWZMLRLA-UHFFFAOYSA-N SMILES Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C Storage condition 2-8°C Stability Stable. Incompatible with strong oxidizing agents. Water Solubility <0.1 g/100 mL at 22.5 ºC
Use ofProperties Articles52 Name sulfisoxazole Synonym More Synonyms Sulfisoxazole Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Research Areas >> Infection References [1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34. [2]. http://www.mayoclinic.org/drugs-supplements/sulfisoxazole-oral-route/description/drg-20072998 Chemical & Physical Properties Molecular Formula C11H13N3O3S Exact Mass 267.067749 PSA 106.60000 Index of Refraction 1.626 InChIKey NHUHCSRWZMLRLA-UHFFFAOYSA-N Stability Stable. Incompatible with strong oxidizing agents.
Tax Rebate9.0%
SupervisionNone MFN tariff: 6.5% Ordinary tariff: 35.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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