| Chemical & Physical Properties | |
|---|---|
| CAS Number | 69097-99-0 |
| Catalog No. | 2A-0202661 |
| Chinese Name | 橙皮素 |
| Synonyms | 3',5,7-Trihydroxy-4'-methoxyflavanone; hesperetine |
| Molecular Formula | C16H14O6 |
| Molecular Weight | 302.279 |
| Melting Point | 227 - 232 °C |
| Appearance | solid |
| Water Solubility | ethanol: soluble50mg/mL, clear to almost clear, co |
| Storage Condition | 2-8°C |
| Application | (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone that is an effective, broad-spectrum inhibitor of human UGT. Hesperetin induces apoptosis by activating p38 MAPK. |
| SMILES | COc1ccc(C2CC(=O)c3c(O)cc(O)cc3O2)cc1O |
| InChI Key | AIONOLUJZLIMTK-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Neurological Disease References [1]. Arya A, et al. Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism. Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:954-964 [2]. Liu D, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39(12):2052-2059. [3]. Shagirtha K, et al. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2016 Nov 1. pii: 0748233716665301 [4]. Li Q, et al. Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation. Nutr Cancer. 2019 Jul 11:1-8. Chemical & Physical Properties Melting Point 227 - 232 °C Molecular Formula C16H14O6 Molecular Weight 302.27900 Exact Mass 302.07900 PSA 96.22000 LogP 2.51850 InChIKey AIONOLUJZLIMTK-UHFFFAOYSA-N SMILES COc1ccc(C2CC(=O)c3c(O)cc(O)cc3O2)cc1O Storage condition 2-8°C Water Solubility ethanol: soluble50mg/mL, clear to almost clear, colorless to slightly yellow |
| Use of | (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Properties Articles18 Name 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one Synonym More Synonyms (Rac)-Hesperetin Biological Activity Description (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Neurological Disease References [1]. Arya A, et al. Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism. Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:954-964 [2]. Liu D, et al. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions. Biol Pharm Bull. 2016;39(12):2052-2059. [3]. Shagirtha K, et al. Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. Toxicol Ind Health. 2016 Nov 1. pii: 0748233716665301 [4]. Li Q, et al. Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation. Nutr Cancer. 2019 Jul 11:1-8. Chemical & Physical Properties Molecular Formula C16H14O6 Exact Mass 302.07900 PSA 96.22000 LogP 2.51850 InChIKey AIONOLUJZLIMTK-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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