CAS Number80-74-0
SynonymsGANTRISIN PEDIATRIC; Acetyl-(3,4-dimethyl-isoxazol-5-yl)-sulfanilyl-amin; Sulfisoxazole acetyl; Lipo Gantrisin; N-(4-amino-benzenesulfonyl)-N-(3,4-dimethyl-isoxazol-5-yl)-acetamide; N-3,4-dimethylisoxazol-5-yl-N-sulfanilylacetamide; UNII-WBT5QH3KED; EINECS 201-305-3; Sulfisoxazole acetal; acetylsulfafurazole; ACETYL SULFISOXAZOLE
Molecular FormulaC13H15N3O4S
Molecular Weight309.34
Density1.404g/cm3
Melting Point193-194°
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 80-74-0 |
| Catalog No. | 2A-4201330 |
| Chinese Name | 乙酰磺胺异噁唑 |
| Synonyms | GANTRISIN PEDIATRIC; Acetyl-(3,4-dimethyl-isoxazol-5-yl)-sulfanilyl-amin; Sulfisoxazole acetyl; Lipo Gantrisin; N-(4-amino-benzenesulfonyl)-N-(3,4-dimethyl-isoxazol-5-yl)-acetamide; N-3,4-dimethylisoxazol-5-yl-N-sulfanilylacetamide; UNII-WBT5QH3KED; EINECS 201-305-3; Sulfisoxazole acetal; acetylsulfafurazole; ACETYL SULFISOXAZOLE |
| Molecular Formula | C13H15N3O4S |
| Molecular Weight | 309.34 |
| Density | 1.404g/cm3 |
| Melting Point | 193-194° |
| Appearance | solid |
| Storage Condition | 2-8°C, sealed, dry |
| Application | Acetyl sulfoxide isoxazole (N1 acetyl sulfoxide isoxazole) is a sulfoxide isoxazole derivative and an orally active dihydropterate synthase inhibitor. Acetyl sulfoxide isoxazole has antibacterial effe |
| HTC | 2935009090 |
| PubChem ID | 603333 |
| MDL Number | MFCD00072139 |
| SMILES | [S](=O)(=O)(N(c2[o]nc(c2C)C)C(=O)C)c1ccc(cc1)N |
| InChI | 1S/C13H15N3O4S/c1-8-9(2)15-20-13(8)16(10(3)17)21(18,19)12-6-4-11(14)5-7-12/h4-7H,14H2,1-3H3 |
| InChI Key | JFNWFXVFBDDWCX-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/203007_1_80_74_0.pdf |
| Use of | Sulfisoxazole acetyl (N1-Acetylsulfisoxazole), a Sulfisoxazole derivative, is an orally active dihydropteroate synthase inhibitor. Sulfisoxazole acetyl has an antibacterial action[1]. Properties Name N-(4-aminophenyl)sulfonyl-N-(3,4-dimethyl-1,2-oxazol-5-yl)acetamide Synonym More Synonyms Description Sulfisoxazole acetyl (N1-Acetylsulfisoxazole), a Sulfisoxazole derivative, is an orally active dihydropteroate synthase inhibitor. Sulfisoxazole acetyl has an antibacterial action[1]. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial In Vitro As with other sulfonamides, the antibacterial action of Sulfisoxazole acetyl (N1-Acetylsulfisoxazole) is attributable to inhibiting dihydropteroate synthase, a key enzyme in folate synthesis in bacteria. Sulfisoxazole acetyl is known to be transformed primarily to sulfisoxazole, partly to N4-acetyl sulfisoxazole (N4AS), and likely also to diacetyl sulfisoxazole (DAS) and other compounds[1]. References [1]. Eunyoung Kim, et al. Simultaneous determination of N(1)-acetyl sulfisoxazole and its metabolites, and relative bioavailability compare to sulfisoxazole in rats. J Pharm Biomed Anal. 2016 Sep 10;129:117-120. Chemical & Physical Properties Molecular Formula C13H15N3O4S Exact Mass 309.07800 PSA 114.88000 LogP 3.27740 Index of Refraction 1.611 InChIKey JFNWFXVFBDDWCX-UHFFFAOYSA-N Safety Information RIDADR NONH for all modes of transport HS Code 2935009090 Synthetic Route Total: 1 Page Sulfisoxazole CAS#:127-69-5 Ethanoic anhydride CAS#:108-24-7 sulfisoxazole a... CAS#:80-74-0 Precursor & DownStream Precursor 2 CAS#:127-69-5 Sulfisoxazole CAS#:108-24-7 Ethanoic anhydride DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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