| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5270-74-6 |
| Catalog No. | 2A-0200922 |
| Chinese Name | 2-(4-氯-3-氨磺酰基苯甲酰基)苯甲酸 |
| Synonyms | 2-[3-(Aminosulfonyl)-4-chlorobenzoyl]-benzonic Acid; 2-(4-Chloro-3-sulphamoylbenzoyl)benzoic acid; EINECS 226-089-8 |
| Molecular Formula | C14H10ClNO5S |
| Molecular Weight | 339.75 |
| Density | 1.537g/cm3 |
| Boiling Point | 638.6ºC at 760mmHg |
| Storage Condition | room temperature |
| Application | Chlorthalidone impurity is a metabolite of Chlorthalidone (HY-15833). Chlorthalidone is a thiazide-like diuretic used in the study of hypertension. |
| HTC | 2935009090 |
| SMILES | [S](=O)(=O)(N)c1c(ccc(c1)C(=O)c2c(cccc2)C(=O)O)Cl |
| InChI | 1S/C14H10ClNO5S/c15-11-6-5-8(7-12(11)22(16,20)21)13(17)9-3-1-2-4-10(9)14(18)19/h1-7H,(H,18,19)(H2,16,20,21) |
| InChI Key | UKRADWWBRBBJLZ-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/202716_1_5270_74_6.pdf |
| Use of | Chlorthalidone impurity is a metabolite of Chlorthalidone (HY-15833). Chlorthalidone is a thiazide-like diuretic used to treat hypertension[1][2]. Properties Name 2-(4-chloro-3-sulfamoylbenzoyl)benzoic acid Synonym More Synonyms Chlorthalidone impurity Biological Activity Description Chlorthalidone impurity is a metabolite of Chlorthalidone (HY-15833). Chlorthalidone is a thiazide-like diuretic used to treat hypertension[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others References [1]. Bauer J, et al. Stability-indicating assay for chlorthalidone formulation: evaluation of the USP analysis and a high-performance liquid chromatographic analysis. J Pharm Sci. 1983 Aug;72(8):924-8. [2]. Barrios V, et al. Which thiazide to choose as add-on therapy for hypertension? Integr Blood Press Control. 2014 Jul 30;7:35-47. Chemical & Physical Properties Exact Mass 338.99700 PSA 122.91000 LogP 3.69770 Index of Refraction 1.641 InChIKey UKRADWWBRBBJLZ-UHFFFAOYSA-N Safety Information Signal Word Warning Hazard Statements H302-H315-H319-H335 Precautionary Statements P301 + P312 + P330-P305 + P351 + P338 RIDADR NONH for all modes of transport HS Code 2935009090 Synthetic Route Total: 1 Page Chlorthalidone CAS#:77-36-1 Chlorthalidone ... CAS#:5270-74-6 Literature: Graf et al. Helvetica Chimica Acta, 1959 , vol. 42, p. 1085,1086 2-(4-chlorosulf... CAS#:68592-12-1 Chlorthalidone ... CAS#:5270-74-6 Literature: Graf et al. Helvetica Chimica Acta, 1959 , vol. 42, p. 1085,1086 2-(3-Amino-4-ch... CAS#:118-04-7 Chlorthalidone ... CAS#:5270-74-6 Literature: Graf et al. Helvetica Chimica Acta, 1959 , vol. 42, p. 1085,1086 Precursor & DownStream Precursor 3 CAS#:77-36-1 Chlorthalidone CAS#:68592-12-1 2-(4-chlorosulf... CAS#:118-04-7 2-(3-Amino-4-ch... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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