CAS Number3564-73-6
Synonyms10,11-dihydro-5-carboxamido-5H-dibenz<b,f>azepine; 10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepin; 10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepine; GP 26-301; 10,11-DIHYDROCARBAMAZEPINE; EINECS 222-649-0; 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide; 10,11-Dihydrocarbamazepine,10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide; MFCD00005072; 10,11-Dihydro-5H-dibenz(b,f)azepine-5-carboxamide; 10,11-Dihydro-5H-dibenzo[b,f]azepine-5-carboxamide; 5H-DIBENZ(b,f)AZEPINE-5-CARBOXAMIDE,10,11-DIHYDRO
Molecular FormulaC15H14N2O
Molecular Weight238.28
Purity99%
Density1.2±0.1 g/cm3
Boiling Point394.5±52.0 °C at 760 mmHg
Melting Point205-210 °C (lit.)
Appearancesolid
EINECS222-649-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3564-73-6 |
| Catalog No. | 2A-0200914 |
| Chinese Name | 双氢卡马西平 |
| Synonyms | 10,11-dihydro-5-carboxamido-5H-dibenz<b,f>azepine; 10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepin; 10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepine; GP 26-301; 10,11-DIHYDROCARBAMAZEPINE; EINECS 222-649-0; 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide; 10,11-Dihydrocarbamazepine,10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide; MFCD00005072; 10,11-Dihydro-5H-dibenz(b,f)azepine-5-carboxamide; 10,11-Dihydro-5H-dibenzo[b,f]azepine-5-carboxamide; 5H-DIBENZ(b,f)AZEPINE-5-CARBOXAMIDE,10,11-DIHYDRO |
| Molecular Formula | C15H14N2O |
| Molecular Weight | 238.28 |
| Purity | 99 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 394.5±52.0 °C at 760 mmHg |
| Melting Point | 205-210 °C (lit.) |
| Appearance | solid |
| Water Solubility | dichloromethane: soluble2.5%, clear, colorless | S |
| Storage Condition | Keep away from light, in a ventilated and dry plac |
| Application | 10,11-Dihydrocarbamazepine is the active metabolite of oxcarbazepine. 10,11-Dihydrocarbamazepine is also an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-dihydrocarba |
| EINECS | 222-649-0 |
| HTC | 2933990090 |
| PubChem ID | 24851693 |
| MDL Number | MFCD00005072 |
| SMILES | NC(=O)N1c2ccccc2CCc3ccccc13 |
| InChI | 1S/C15H14N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-8H,9-10H2,(H2,16,18) |
| InChI Key | PHNLCHMJDSSPDQ-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | transportation |
| MSDS | msds/202708_1_3564_73_6.pdf |
| Bioactivity | 10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vitro Oxcarbazepine is metabolized in the liver to its active metabolite, 10,11-Dihydrocarbamazepine. Oxcarbazepine is an antiepileptic drug (AED) used to treat partial seizures as a monotherapy or adjunctive therapy[1]. 10,11-Dihydrocarbamazepine may be used as a reference standard for the determination of 10,11-dihydrocarbamazepine in pharmaceutical formulations by liquid chromatography (LC)[1]. References [1]. Courtney Hunek, et al. Measurement of 10,11-dihydro-10-hydroxy-carbamazepine in serum and plasma by high-performance liquid chromatography. Clin Chem Lab Med. 2008;46(10):1429-33. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 394.5±52.0 °C at 760 mmHg Melting Point 205-210ºC Molecular Formula C15H14N2O Molecular Weight 238.28 Flash Point 192.4±30.7 °C Exact Mass 238.110611 PSA 46.33000 LogP 2.60 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.645 InChIKey PHNLCHMJDSSPDQ-UHFFFAOYSA-N SMILES NC(=O)N1c2ccccc2CCc2ccccc21 Storage condition Refrigerator Water Solubility dichloromethane: soluble2.5%, clear, colorless | Soluble in dichloromethane. Insoluble in water. |
| Use of | 10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy[1]. Properties Name 5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide Synonym More Synonyms 10,11-Dihydrocarbamazepine Biological Activity Description 10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vitro Oxcarbazepine is metabolized in the liver to its active metabolite, 10,11-Dihydrocarbamazepine. Oxcarbazepine is an antiepileptic drug (AED) used to treat partial seizures as a monotherapy or adjunctive therapy[1]. 10,11-Dihydrocarbamazepine may be used as a reference standard for the determination of 10,11-dihydrocarbamazepine in pharmaceutical formulations by liquid chromatography (LC)[1]. References [1]. Courtney Hunek, et al. Measurement of 10,11-dihydro-10-hydroxy-carbamazepine in serum and plasma by high-performance liquid chromatography. Clin Chem Lab Med. 2008;46(10):1429-33. Chemical & Physical Properties Molecular Formula C15H14N2O Exact Mass 238.110611 PSA 46.33000 Index of Refraction 1.645 InChIKey PHNLCHMJDSSPDQ-UHFFFAOYSA-N Storage condition Refrigerator Water Solubility dichloromethane: soluble2.5%, clear, colorless | Soluble in dichloromethane. Insoluble in water. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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