| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2163-11-3 |
| Catalog No. | 2A-1200524 |
| Chinese Name | Tetrahydropyranyldiethyleneglycol |
| Synonyms | 2-[2-(oxan-2-yloxy)ethoxy]ethanol |
| Molecular Formula | C9H18O4 |
| Molecular Weight | 190.24 |
| Storage Condition | -20°C, dry, sealed |
| Application | Tetrahydropyranyldiethyleneglycol is a PROTAC linker, belonging to the PEG class. Tetrahydropyranyldiethyleneglycol can be used to synthesize PROTAC molecules. |
| HTC | 2932999099 |
| PubChem ID | 6536796 |
| MDL Number | MFCD03425638 |
| SMILES | OCCOCCOC1CCCCO1 |
| InChI | InChI=1S/C9H18O4/c10-4-6-11-7-8-13-9-3-1-2-5-12-9/h9-10H,1-8H2 |
| InChI Key | CPCUDERUJBARLD-UHFFFAOYSA-N |
| MSDS | msds/202432_1_2163_11_3.pdf |
| Use of | Tetrahydropyranyldiethyleneglycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name Tetrahydropyranyldiethyleneglycol Synonym More Synonyms Tetrahydropyranyldiethyleneglycol Biological Activity Description Tetrahydropyranyldiethyleneglycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Molecular Formula C9H18O4 Exact Mass 190.12100 PSA 47.92000 LogP 0.53850 InChIKey CPCUDERUJBARLD-UHFFFAOYSA-N Safety Information HS Code 2932999099 Synthetic Route Total: 1 Page Tetrahydropyran CAS#:142-68-7 Diethylene glycol CAS#:111-46-6 Tetrahydropyran... CAS#:2163-11-3 3,4-Dihydro-2H-pyran CAS#:110-87-2 Diethylene glycol CAS#:111-46-6 Tetrahydropyran... CAS#:2163-11-3 Literature: Liu, Xiao; Tian, Zhicheng; Chen, Chen; Allcock, Harry R. Macromolecules, 2012 , vol. 45, # 3 p. 1417 - 1426 Precursor & DownStream Precursor 3 CAS#:142-68-7 Tetrahydropyran CAS#:111-46-6 Diethylene glycol CAS#:110-87-2 3,4-Dihydro-2H-pyran DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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