| Chemical & Physical Properties | |
|---|---|
| CAS Number | 10297-09-3 |
| Catalog No. | 2A-1198893 |
| Chinese Name | 7-Octynoic acid |
| Synonyms | 7-Octynoic acid; Oct-7-insaeure |
| Molecular Formula | C8H12O2 |
| Molecular Weight | 140.18 |
| Appearance | colorless oil |
| Storage Condition | 2-8℃ |
| Application | 7-Octynoic acid (compound 42) is a PROTAC bridge. 7-Octynoic acid can be used to synthesize a range of PROTAC molecules. PROTAC molecules contain two different ligands connected by a linking bridge; o |
| HTC | 2916190090 |
| MDL Number | MFCD19228078 |
| SMILES | C#CCCCCCC(=O)O |
| InChI Key | WJBHDZBQZOMDFF-UHFFFAOYSA-N |
| MSDS | msds/200838_1_10297_09_3.pdf |
| Use of | 7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. Properties Name oct-7-ynoic acid Synonym More Synonyms 7-Octynoic acid Biological Activity Description 7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. Related Catalog Research Areas >> Cancer References [1]. Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17. Chemical & Physical Properties Molecular Formula C8H12O2 Exact Mass 140.08400 PSA 37.30000 LogP 1.65470 InChIKey WJBHDZBQZOMDFF-UHFFFAOYSA-N SMILES C#CCCCCCC(=O)O Storage condition 2-8℃ Safety Information HS Code 2916190090 Synthetic Route 7-Octyn-1-ol 7-Octynoic acid 10297-09-3 Literature: Yeagley, Andrew A.; Su, Zhaoming; McCullough, Kara D.; Worthington, Roberta J.; Melander, Christian Organic and Biomolecular Chemistry, 2013 , vol. 11, # 1 p. 130 - 137 3-Octyn-1-ol 14916-80-4 7-Octynoic acid 10297-09-3 Literature: Reyes, Samuel; Huigens Iii, Robert W.; Su, Zhaoming; Simon, Michel L.; Melander, Christian Organic and Biomolecular Chemistry, 2011 , vol. 9, # 8 p. 3041 - 3049 6-Bromohexanoic... sodium acetylid... 7-Octynoic acid 10297-09-3 Literature: Zinkevich,E.P. et al. Zhurnal Organicheskoi Khimii, 1966 , vol. 2, # 11 p. 2028 - 2031,1990 - 1992 Precursor & DownStream Precursor 10 CAS#:871-91-0 7-Octyn-1-ol CAS#:14916-80-4 3-Octyn-1-ol CAS#:4224-70-8 6-Bromohexanoic acid CAS#:1066-26-8 sodium acetylide DownStream 10 CAS#:506-13-8 16-hydroxypalmi... CAS#:2536-36-9 CAS#:111-16-0 Pimelic acid CAS#:871-91-0 7-Octyn-1-ol |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Imported food hygiene supervision and inspection S. Export food hygiene supervision and inspection M. Imported commodity inspection N. Exported commodity inspection |
| Transport Info | Product name: Supervision conditions A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
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