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Home > Products > Pharmaceutical R&D Materials > Heterocyclic Building Blocks > 2-(CHLOROMETHYL)-4-(4-NITROPHENYL)-1,3-THIAZOLE
2-(CHLOROMETHYL)-4-(4-NITROPHENYL)-1,3-THIAZOLE structure, CAS 89250-26-0

2-(CHLOROMETHYL)-4-(4-NITROPHENYL)-1,3-THIAZOLE

CAS Number89250-26-0

Synonyms2-(chloromethyl)-4-(4-nitrophenyl)-1,3-thiazole

Molecular FormulaC12H12N2O2S

Molecular Weight248.306

Purity

Density1.4±0.1 g/cm3

Boiling Point406.2±30.0 °C at 760 mmHg

Melting Point154.5ºC

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-2198856 Purity:
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Quality Control of [ 89250-26-0 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number89250-26-0
Catalog No.2A-2198856
Chinese Name黄芪多糖
Synonyms2-(chloromethyl)-4-(4-nitrophenyl)-1,3-thiazole
Molecular FormulaC12H12N2O2S
Molecular Weight248.306
Density1.4±0.1 g/cm3
Boiling Point406.2±30.0 °C at 760 mmHg
Melting Point154.5ºC
Appearancesolid
Storage ConditionRoom temperature, dry, sealed
Application2-(Chloromethyl)-4-(4-nitrophenyl)thiazole (Compound APS) has anticancer activity in hepatocellular carcinoma (HCC) by inhibiting M2 polarization of tumor-associated macrophages (TAMs). 2-(Chloromethy
HTC2932999099
MDL NumberMFCD03087883
SMILESO=[N+]([O-])c1ccc(-c2csc(CCl)n2)cc1
InChI KeyLEBRGKZHLICZCZ-UHFFFAOYSA-N
MSDSmsds/200800_1_89250_26_0.pdf
Use of2-(Chloromethyl)-4-(4-nitrophenyl)thiazole (Compound APS) has anti-cancer activity in hepatocellular carcinoma (HCC) by repression of M2 polarization of Tumor-associated macrophages (TAMs). 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole can be isolated from Astragalus propinquus Schischk[1]. Properties Name 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole Synonym More Synonyms Biological Activity Description 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole (Compound APS) has anti-cancer activity in hepatocellular carcinoma (HCC) by repression of M2 polarization of Tumor-associated macrophages (TAMs). 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole can be isolated from Astragalus propinquus Schischk[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Li C, et al. Astragalus polysacharin inhibits hepatocellular carcinoma-like phenotypes in a murine HCC model through repression of M2 polarization of tumour-associated macrophages. Pharm Biol. 2021 Dec;59(1):1533-1539. Chemical & Physical Properties Exact Mass 253.991669 PSA 86.95000 Index of Refraction 1.638 InChIKey LEBRGKZHLICZCZ-UHFFFAOYSA-N Safety Information Hazard Codes Xi Risk Phrases 34 HS Code 2932999099 Synthetic Route [4-(4-nitro-phe... CAS#:4414-98-6 2-(Chloromethyl... CAS#:89250-26-0 Literature: Zhurnal Obshchei Khimii, , vol. 24, p. 1059,1062; engl. Ausg. S. 1057, 1060 CAS#:4414-97-5 2-(Chloromethyl... CAS#:89250-26-0 Literature: Zhurnal Obshchei Khimii, , vol. 24, p. 1059,1062; engl. Ausg. S. 1057, 1060 p-nitrophenacyl... CAS#:99-81-0 2-(Chloromethyl... CAS#:89250-26-0 Literature: Zhurnal Obshchei Khimii, , vol. 24, p. 1059,1062; engl. Ausg. S. 1057, 1060 Precursor & DownStream Precursor 3 CAS#:4414-98-6 [4-(4-nitro-phe... CAS#:99-81-0 p-nitrophenacyl... CAS#:65385-00-4 2-(Chloromethyl... DownStream 1 CAS#:25021-46-9 Thiazole,4-(4-n...
Tax Rebate9.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
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