CAS Number106083-71-0
Synonyms(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol,hydrochloride; Radafaxine (hydrochloride)
Molecular FormulaC13H19Cl2NO2
Molecular Weight292.20
Purity≥98 (HPLC)%
Density1.144g/cm3
Boiling Point386.6ºC at 760mmHg
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 106083-71-0 |
| Catalog No. | 2A-1198677 |
| Chinese Name | 盐酸Radafaxine |
| Synonyms | (2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol,hydrochloride; Radafaxine (hydrochloride) |
| Molecular Formula | C13H19Cl2NO2 |
| Molecular Weight | 292.20 |
| Purity | ≥98 (HPLC) |
| Density | 1.144g/cm3 |
| Boiling Point | 386.6ºC at 760mmHg |
| Appearance | powder |
| Storage Condition | 2-8℃ |
| Application | Radafaxine hydrochloride is a metabolic activator of bupropion, a DAT/NET transporter inhibitor, and can inhibit the reabsorption of norepinephrine. |
| HTC | 2922509090 |
| PubChem ID | 329815193 |
| MDL Number | MFCD10565921 |
| SMILES | Cl.C[C@@H]1NC(C)(C)CO[C@@]1(O)c2cccc(Cl)c2 |
| InChI | 1S/C13H18ClNO2.ClH/c1-9-13(16,17-8-12(2,3)15-9)10-5-4-6-11(14)7-10;/h4-7,9,15-16H,8H2,1-3H3;1H/t9-,13+;/m0./s1 |
| InChI Key | ORXTVTDGPVINDN-BTJVGWIPSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/200612_1_106083_71_0.pdf |
| Bioactivity | Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Monoamine Transporter Research Areas >> Neurological Disease References [1]. Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19(3):163-70. [2]. Bondarev ML, et al. Behavioral and biochemical investigations of bupropion metabolites. Eur J Pharmacol. 2003 Aug 1;474(1):85-93. Chemical & Physical Properties Density 1.144g/cm3 Boiling Point 386.6ºC at 760mmHg Molecular Formula C13H19Cl2NO2 Molecular Weight 292.20100 Flash Point 187.6ºC Exact Mass 291.07900 PSA 41.49000 LogP 3.40280 Vapour Pressure 0mmHg at 25°C Index of Refraction 1.523 Storage condition 2-8℃ |
| Use of | Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator. Properties Name (2S,3S)-Hydroxybupropion hydrochloride Synonym More Synonyms Radafaxine (hydrochloride) Biological Activity Description Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Monoamine Transporter Research Areas >> Neurological Disease References [1]. Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19(3):163-70. [2]. Bondarev ML, et al. Behavioral and biochemical investigations of bupropion metabolites. Eur J Pharmacol. 2003 Aug 1;474(1):85-93. Chemical & Physical Properties Exact Mass 291.07900 PSA 41.49000 LogP 3.40280 Index of Refraction 1.523 Storage condition 2-8℃ |
| Tax Rebate | 13.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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