CAS Number620-67-7
SynonymsTriheptanoin; Glycerol-1,2,3-triheptanoate; TRIHEPTANION; trioenanthoin; Propane-1,2,3-triyl triheptanoate; trienanthoin; propane-1,2,3-triyl trisheptanoate; 1,2,3-Propanetriyl triheptanoate; glyceryl triheptanoate; glycerol trienanthate; 1,2,3-tris-heptanoyloxy-propane; glyceroltriheptanoate; triheptylin; tri-heptanoi; 1,2,3-Tris-heptanoyloxy-propan; Heptanoic acid, 1,2,3-propanetriyl ester; triheptanoicglyceride; TRIOENANTHIN
Molecular FormulaC24H44O6
Molecular Weight428.60
Purity≥95 (HPLC)%
Density1.0±0.1 g/cm3
Boiling Point470.0±12.0 °C at 760 mmHg
Appearanceoil
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 620-67-7 |
| Catalog No. | 2A-1198448 |
| Chinese Name | 三庚酸甘油酯 |
| Synonyms | Triheptanoin; Glycerol-1,2,3-triheptanoate; TRIHEPTANION; trioenanthoin; Propane-1,2,3-triyl triheptanoate; trienanthoin; propane-1,2,3-triyl trisheptanoate; 1,2,3-Propanetriyl triheptanoate; glyceryl triheptanoate; glycerol trienanthate; 1,2,3-tris-heptanoyloxy-propane; glyceroltriheptanoate; triheptylin; tri-heptanoi; 1,2,3-Tris-heptanoyloxy-propan; Heptanoic acid, 1,2,3-propanetriyl ester; triheptanoicglyceride; TRIOENANTHIN |
| Molecular Formula | C24H44O6 |
| Molecular Weight | 428.60 |
| Purity | ≥95 (HPLC) |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 470.0±12.0 °C at 760 mmHg |
| Appearance | oil |
| Storage Condition | room temperature |
| Application | Triheptanoate (propane-1,2,3-tripropyltriheptanoate) is a synthetic medium-chain triglyceride (MCT) composed of three odd-chain 7-carbon (heptanoate) fatty acids on the glycerol backbone. Triheptanoic |
| HTC | 2915900090 |
| MDL Number | MFCD00042910 |
| SMILES | O(C(COC(=O)CCCCCC)COC(=O)CCCCCC)C(=O)CCCCCC |
| InChI | 1S/C24H44O6/c1-4-7-10-13-16-22(25)28-19-21(30-24(27)18-15-12-9-6-3)20-29-23(26)17-14-11-8-5-2/h21H,4-20H2,1-3H3 |
| InChI Key | PJHKBYALYHRYSK-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 23201100 |
| Hazard Symbols | transportation |
| MSDS | msds/200352_1_620_67_7.pdf |
| Bioactivity | Triheptanoin (Propane-1,2,3-triyl triheptanoate) is a synthetic medium-chain triglyceride (MCT) consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. Triheptanoin can be used for the research of inherited metabolic disorders[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vivo In long-chain fatty acid oxidation disorders (LC-FAOD), Triheptanoin is used as an anaplerotic compound, acting as a source of calories and fatty acids to bypass the LC-FAOD enzyme deficiencies[1]. Triheptanoin can be used for the research of ataxia-telangiectasia (A-T)[2]. Triheptanoin functions as an anaplerotic agent replenishing tricarboxylic acid (TCA) cycle intermediates by metabolism to heptanoate (C7) and subsequently acetyl-CoA and propionyl-CoA that feed into the TCA cycle to supply energy[2]. Triheptanoin mitigates brain ATP depletion and mitochondrial dysfunction, including respiration and redox balance in a mouse model of Alzheimer's disease, supporting the energy failure hypothesis for that disorder[2]. Triheptanoin (Mice were treated with Triheptanoin (35E%) for 10 days prior to pilocarpine injection to induce status epilepticus) preserved mitochondrial functions in the hippocampal formations of pilocarpine-induced status epilepticus (SE) mice[3]. Animal Model: 7-8 week old male CD1 (35-40 g)[3] Dosage: 35E% oral Triheptanoin was mixed into mouse chow Administration: Given 35E% Triheptanoin treatment 10 days prior to SE induction Result: Preserved mitochondrial functions in SE mice. References [1]. Matt Shirley. Triheptanoin: First Approval. Drugs. 2020 Oct;80(15):1595-1600. [2]. A J Yeo, et al. An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T). Mol Metab. 2021 Dec;54:101354. [3]. Kah Ni Tan, et al. Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. J Neurochem. 2018 Feb;144(4):431-442. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 470.0±12.0 °C at 760 mmHg Molecular Formula C24H44O6 Molecular Weight 428.603 Flash Point 195.5±19.6 °C Exact Mass 428.313782 PSA 78.90000 LogP 7.73 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.457 InChIKey PJHKBYALYHRYSK-UHFFFAOYSA-N SMILES CCCCCCC(=O)OCC(COC(=O)CCCCCC)OC(=O)CCCCCC |
| Use of | Triheptanoin (Propane-1,2,3-triyl triheptanoate) is a synthetic medium-chain triglyceride (MCT) consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. Triheptanoin can be used for the research of inherited metabolic disorders[1]. Properties Name triheptanoin Synonym More Synonyms TRIHEPTANOIN Biological Activity Description Triheptanoin (Propane-1,2,3-triyl triheptanoate) is a synthetic medium-chain triglyceride (MCT) consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. Triheptanoin can be used for the research of inherited metabolic disorders[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Matt Shirley. Triheptanoin: First Approval. Drugs. 2020 Oct;80(15):1595-1600. [2]. A J Yeo, et al. An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T). Mol Metab. 2021 Dec;54:101354. [3]. Kah Ni Tan, et al. Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. J Neurochem. 2018 Feb;144(4):431-442. Chemical & Physical Properties Molecular Formula C24H44O6 Exact Mass 428.313782 PSA 78.90000 Index of Refraction 1.457 InChIKey PJHKBYALYHRYSK-UHFFFAOYSA-N SMILES CCCCCCC(=O)OCC(COC(=O)CCCCCC)OC(=O)CCCCCC |
| Tax Rebate | 9.0% |
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| Inspection | R. Imported food hygiene supervision and inspection S. Export food hygiene supervision and inspection M. Imported commodity inspection N. Exported commodity inspection |
| Transport Info | Product name: Purity: 94.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3082 International Maritime Danger Regulations: 3082 International Air Transport Danger Regulations: 3082 14.2 Names specified by the United Nations (UN) European land transport hazard regulations: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (Propane-1,2,3-triyl trisheptanoate) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (Propane-1,2,3-triyl trisheptanoate) International air transport hazard regulations: Environmentally hazardous substance, liquid, n.o.s. (Propane-1,2,3-triyl trisheptanoate) 14.3 Transport hazard categories European land transport Dangerous Regulations: 9 International sea transport Dangerous Regulations: 9 International air transport Dangerous Regulations: 9 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: Yes International Maritime Transport Dangerous Regulations Maritime Pollutants: Yes International Air Transport Dangerous Regulations: Yes 14.6 Special reminder to users further information Dangerous goods are individually packaged, with liquids exceeding 5 liters or solids exceeding 5 kilograms. The outer packaging of each independent package and the combined independent inner package must have EHS on it. Identification (according to European ADR Regulation 2.2.9.1.10, IMDG Regulation 2.10.3), |
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