CAS Number857891-82-8
SynonymsAzido-PEG-amine (n=8); O-(2-Aminoethyl)-O'-(2-azidoethyl)heptaethylene glycol; O-(2-Aminoethyl)-O inverted exclamation marka-(2-azidoethyl)heptaethylene glycol; 26-Azido-3,6,9,12,15,18,21,24-octaoxahexacosan-1-amine
Molecular FormulaC18H38N4O8
Molecular Weight438.52
Purity≥90 (oligomer purity)%
Appearanceliquid
Symbol
Signal WordWarning
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 857891-82-8 |
| Catalog No. | 2A-1198324 |
| Chinese Name | O-(2-氨基乙基)-O′-(2-叠氮乙基)七聚乙二醇 |
| Synonyms | Azido-PEG-amine (n=8); O-(2-Aminoethyl)-O'-(2-azidoethyl)heptaethylene glycol; O-(2-Aminoethyl)-O inverted exclamation marka-(2-azidoethyl)heptaethylene glycol; 26-Azido-3,6,9,12,15,18,21,24-octaoxahexacosan-1-amine |
| Molecular Formula | C18H38N4O8 |
| Molecular Weight | 438.52 |
| Purity | ≥90 (oligomer purity) |
| Appearance | liquid |
| Storage Condition | 2-8°C |
| Application | Azido-PEG8-amine is a PROTAC linker and belongs to the PEG class. Can be used to synthesize PROTAC molecules. |
| PubChem ID | 57652634 |
| MDL Number | MFCD03453241 |
| SMILES | NCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] |
| InChI | 1S/C18H38N4O8/c19-1-3-23-5-7-25-9-11-27-13-15-29-17-18-30-16-14-28-12-10-26-8-6-24-4-2-21-22-20/h1-19H2 |
| InChI Key | ZSFGTBJYBWJOLZ-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/200216_1_857891_82_8.pdf |
| Bioactivity | Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target PEGs In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C18H38N4O8 Molecular Weight 438.51600 Exact Mass 438.26900 PSA 149.61000 LogP 0.54126 InChIKey ZSFGTBJYBWJOLZ-UHFFFAOYSA-N SMILES [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCN Storage condition 2-8°C |
| Use of | Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name 2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine Synonym More Synonyms Azido-PEG8-amine Biological Activity Description Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C18H38N4O8 Exact Mass 438.26900 PSA 149.61000 LogP 0.54126 InChIKey ZSFGTBJYBWJOLZ-UHFFFAOYSA-N SMILES [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCN |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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| Mal-PEG3-Mal | 1008402-47-8 | 2A-1198319 |
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| H2N-PEG12-OH | 198277-38-2 | 2A-1198321 |
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| alpha-aMine-oMega-propionic acid octaethylene glycol | 756526-04-2 | 2A-1198328 |
| Azido-PEG12-acid | 1167575-20-3 | 2A-1198329 |
| 5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80,83,86-Octacosaoxa-2-azanonaoctacontanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester | 2101605-02-9 | 2A-1198330 |
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