| Chemical & Physical Properties | |
|---|---|
| CAS Number | 756526-03-1 |
| Catalog No. | 2A-1198313 |
| Chinese Name | 双(NHS)PEG5 |
| Synonyms | Bis-PEG5-NHS ester; AmbotzPEG1435; BIS-SUCCINIMIDYL-4,7,10,13,16-PENTAOXANONADECANE-1,19-DIOATE; B3728; Bis-dPEG5-NHS ester |
| Molecular Formula | C22H32N2O13 |
| Molecular Weight | 532.50 |
| Appearance | liquid |
| Water Solubility | Pure compounds with defined structure and molecula |
| Storage Condition | -20°C, argon-filled storage |
| Application | Bis-PEG5-NHS ester is a cleavable ADC bridge for the synthesis of antibody drug conjugates (ADCs). |
| MDL Number | MFCD11041118 |
| SMILES | N2(C(=O)CCC2=O)OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O |
| InChI Key | FTYUGLBWKRXQBD-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352200 |
| MSDS | msds/200205_1_756526_03_1.pdf |
| Bioactivity | Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Target Cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. References [1]. Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1. Chemical & Physical Properties Molecular Formula C22H32N2O13 Molecular Weight 532.49500 Exact Mass 532.19000 PSA 173.51000 InChIKey FTYUGLBWKRXQBD-UHFFFAOYSA-N SMILES O=C(CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O |
| Use of | Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Properties Name (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate Synonym More Synonyms Bis-PEG5-NHS ester Biological Activity Description Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. References [1]. Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1. Chemical & Physical Properties Molecular Formula C22H32N2O13 Exact Mass 532.19000 PSA 173.51000 InChIKey FTYUGLBWKRXQBD-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| HS-PEG4-CH2CH2COOH | 749247-06-1 | 2A-1198308 |
| 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47-Hexadecaoxanonatetracontan-49-ol | 133604-58-7 | 2A-1198309 |
| MPEG3-Propyne | 89635-82-5 | 2A-1198310 |
| MPEG6-CH2CH2COOH | 874208-91-0 | 2A-1198311 |
| N3-PEG23-CH2CH2NH2 | 749244-38-0 | 2A-1198312 |
| [2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid | 16142-03-3 | 2A-1198317 |
| mPEG12-Br | 1620461-89-3 | 2A-1198318 |
| Mal-PEG3-Mal | 1008402-47-8 | 2A-1198319 |
| Amino-PEG12-alcohol | 933789-97-0 | 2A-1198320 |
| H2N-PEG12-OH | 198277-38-2 | 2A-1198321 |
| Browse all Specialty Chemicals products » | ||
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