| Chemical & Physical Properties | |
|---|---|
| CAS Number | 875770-34-6 |
| Catalog No. | 2A-1198302 |
| Chinese Name | N-[2-[2-[2-(2-叠氮乙氧基)乙氧基]乙氧基]乙基]生物素胺 |
| Synonyms | Biotin-PEG3-Azide |
| Molecular Formula | C18H32N6O5S |
| Molecular Weight | 444.55 |
| Melting Point | 110 °C |
| Appearance | solid |
| Storage Condition | <0°C; avoid heating |
| Application | Biotin-PEG3-azide is a PROTAC linker based on PEG structure and can be used for the synthesis of PROTAC. |
| PubChem ID | 329766598 |
| MDL Number | MFCD20134145 |
| SMILES | O=C1N[C@](CS[C@H]2CCCCC(NCCOCCOCCOCCN=[N+]=[N-])=O)([H])[C@]2([H])N1 |
| InChI | 1S/C18H32N6O5S/c19-24-21-6-8-28-10-12-29-11-9-27-7-5-20-16(25)4-2-1-3-15-17-14(13-30-15)22-18(26)23-17/h14-15,17H,1-13H2,(H,20,25)(H2,22,23,26)/t14-,15-,17-/m1/s1 |
| InChI Key | ZWFOOMQCYIGZBE-BFYDXBDKSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352125 |
| Hazard Symbols | transportation |
| MSDS | msds/200194_1_875770_34_6.pdf |
| Bioactivity | Biotin-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target PEGs In Vitro Biotin-C2-PEG3-azide is a biotin with the azide tag, it can be conjugated to antiviral inhibitors, for example, RYL-634, which shows excellent broad-spectrum inhibition activity against various pathogenic viruses, including hepatitis C virus, dengue virus, Zika virus, chikungunya virus, enterovirus[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. References [1]. Yang Y, et al. Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors.J Med Chem. 2019 Apr 25;62(8):4056-4073. Chemical & Physical Properties Melting Point 110 °C Molecular Formula C18H32N6O5S Molecular Weight 444.549 Exact Mass 444.215485 PSA 179.95000 LogP -0.93 InChIKey ZWFOOMQCYIGZBE-ZOBUZTSGSA-N SMILES [N-]=[N+]=NCCOCCOCCOCCNC(=O)CCCCC1SCC2NC(=O)NC21 |
| Use of | Biotin-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Properties Name 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]pentanamide Synonym More Synonyms Biotin-PEG3-azide Biological Activity Description Biotin-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro Biotin-C2-PEG3-azide is a biotin with the azide tag, it can be conjugated to antiviral inhibitors, for example, RYL-634, which shows excellent broad-spectrum inhibition activity against various pathogenic viruses, including hepatitis C virus, dengue virus, Zika virus, chikungunya virus, enterovirus[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. References [1]. Yang Y, et al. Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors.J Med Chem. 2019 Apr 25;62(8):4056-4073. Chemical & Physical Properties Molecular Formula C18H32N6O5S Exact Mass 444.215485 PSA 179.95000 LogP -0.93 InChIKey ZWFOOMQCYIGZBE-ZOBUZTSGSA-N SMILES [N-]=[N+]=NCCOCCOCCOCCNC(=O)CCCCC1SCC2NC(=O)NC21 |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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