CAS Number19350-66-4
Synonyms2,6-Dimethyl-1,4-dihydro-pyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester; 2.6-dimethyl-3,5-diethoxycarbonyl-1-4-dihydroisonicotinic acid; 3,5-Diethoxycarbonyl-2,6-dimethyl-1,4-dihydroisonicotinsaeure; 2,6-Dimethyl-3,5-diethoxycarbonyl-1,4-dihydro-pyridin-4-carbonsaeure; 3,4,5-pyridinetricarboxylic acid,1,4-dihydro-2,6-dimethyl-,3,5-diethyl ester; 2,5-DIISOPROPYLPHENOL
Molecular FormulaC14H19NO6
Molecular Weight297.311
Density1.23g/cm3
Boiling Point450.5ºC at 760mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 19350-66-4 |
| Catalog No. | 2A-1197606 |
| Chinese Name | 3,5-二(乙氧羰基)-2,6-二甲基-1,4-二氢吡啶-4-羧酸 |
| Synonyms | 2,6-Dimethyl-1,4-dihydro-pyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester; 2.6-dimethyl-3,5-diethoxycarbonyl-1-4-dihydroisonicotinic acid; 3,5-Diethoxycarbonyl-2,6-dimethyl-1,4-dihydroisonicotinsaeure; 2,6-Dimethyl-3,5-diethoxycarbonyl-1,4-dihydro-pyridin-4-carbonsaeure; 3,4,5-pyridinetricarboxylic acid,1,4-dihydro-2,6-dimethyl-,3,5-diethyl ester; 2,5-DIISOPROPYLPHENOL |
| Molecular Formula | C14H19NO6 |
| Molecular Weight | 297.311 |
| Density | 1.23g/cm3 |
| Boiling Point | 450.5ºC at 760mmHg |
| Storage Condition | Room temperature, store in inert gas |
| Application | AV-153 free base is a 1,4-dihydropyridine (1,4-DHP) derivative with antimutagenic effects. In human cells in vitro, AV-153 free base can insert into single-strand breaks in DNA, reducing DNA damage an |
| HTC | 2933399090 |
| MDL Number | MFCD00417306 |
| SMILES | CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1C(=O)O |
| InChI Key | USGQSNVLGQWBEC-UHFFFAOYSA-N |
| MSDS | msds/199453_1_19350_66_4.pdf |
| Use of | AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity[1][2][3]. Properties Name 3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylic acid Synonym More Synonyms AV-153 free base Biological Activity Description AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity[1][2][3]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis References [1]. Nadezhda I Ryabokon, et al. A 1,4-dihydropyridine Derivative Reduces DNA Damage and Stimulates DNA Repair in Human Cells in Vitro. Mutat Res. 2005 Nov 10;587(1-2):52-8. [2]. E Buraka, et al. DNA-binding Studies of AV-153, an Antimutagenic and DNA Repair-Stimulating Derivative of 1,4-dihydropiridine. Chem Biol Interact. 2014 Sep 5;220:200-7. [3]. Lidija Milkovic, et al. Antioxidative 1,4-Dihydropyridine Derivatives Modulate Oxidative Stress and Growth of Human Osteoblast-Like Cells In Vitro. Antioxidants (Basel). 2018 Sep 19;7(9):123. Chemical & Physical Properties Molecular Formula C14H19NO6 Exact Mass 297.12100 PSA 101.93000 LogP 1.29340 Index of Refraction 1.51 InChIKey USGQSNVLGQWBEC-UHFFFAOYSA-N Safety Information HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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