![[(3E)-3-[[4-[(Z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)norbornan-2-yliden e]methyl]phenyl]methylidene]-7,7-dimethyl-2-oxo-norbornan-1-yl]methane sulfonic acid structure, CAS 92761-26-7](/structures/210000/198442_1_92761_26_7.png)
CAS Number92761-26-7
SynonymsMexoryl SX; 3,3'-(1,4-Phenylenedimethylidyne)bis(7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfonic acid); Terephthalylidene-3,3'-dicamphor-10,10'-disulfonic Acid
Molecular FormulaC28H34O8S2
Molecular Weight562.69
Purity≥97.0 (T)%
Density1.4±0.1 g/cm3
Melting Point255° (dec)
Appearancedark yellow powder
EINECS410-960-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 92761-26-7 |
| Catalog No. | 2A-2196662 |
| Chinese Name | 依莰舒 |
| Synonyms | Mexoryl SX; 3,3'-(1,4-Phenylenedimethylidyne)bis(7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfonic acid); Terephthalylidene-3,3'-dicamphor-10,10'-disulfonic Acid |
| Molecular Formula | C28H34O8S2 |
| Molecular Weight | 562.69 |
| Purity | ≥97.0 (T) |
| Density | 1.4±0.1 g/cm3 |
| Melting Point | 255° (dec) |
| Appearance | dark yellow powder |
| Storage Condition | Room temperature, sealed, dry, inert gas |
| Application | Ecamsule is a broad spectrum UVA filter that can be used in sunscreen products. Ecamsule reduces biological damage caused by solar radiation, such as pyrimidine dimer formation, p53 protein accumulati |
| EINECS | 410-960-6 |
| PubChem ID | 85335578 |
| SMILES | CC1(C)C2CCC1(CS(O)(=O)=O)C(=O)\C2=C/c3ccc(cc3)\C=C4\C5CCC(CS(O)(=O)=O)(C4=O)C5(C)C |
| InChI | 1S/C28H34O8S2/c1-25(2)21-9-11-27(25,15-37(31,32)33)23(29)19(21)13-17-5-7-18(8-6-17)14-20-22-10-12-28(24(20)30,26(22,3)4)16-38(34,35)36/h5-8,13-14,21-22H,9-12,15-16H2,1-4H3,(H,31,32,33)(H,34,35,36)/b19-13-,20-14+ |
| InChI Key | HEAHZSUCFKFERC-LRVMPXQBSA-N |
| Beilstein/REAXYS | 8371688 |
| NACRES Code | NA.24 |
| UNSPSC | 77101502 |
| Hazard Symbols | transportation |
| MSDS | msds/198442_1_92761_26_7.pdf |
| Bioactivity | Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) [1] [2]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vitro Ecamsule is a broad-spectrum UVA-absorber with maximum absorbance at 344 nm[1]. Wild-type Fibs E6/E7 cells are more sensitive towards Ecamsule (200-1600 μM) treatment[1]. . Ecamsule counteractes UV and AAPH induced ROS-formation[1]. .The effects are dose-dependent, reaching a maxi-mum ROS reduction by 25.7% at the highest tested concentration of 1600 μM in the UV-setting. With the same concentration of Ecamsule, oxidative stress that had been trigged by AAPH is reduced by 10.8% and basal levels are attenuated by 16.9%[1]. . Ecamsule increases the viability at the highest applied concentration of 1600 μM in the AAPH-treated cells[1]. References [1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244. [2]. DeLeo VA, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Melting Point 255° (dec) Molecular Formula C28H34O8S2 Molecular Weight 562.695 Exact Mass 562.169495 PSA 159.64000 LogP 1.35 Index of Refraction 1.631 InChIKey HEAHZSUCFKFERC-UHFFFAOYSA-N SMILES CC1(C)C2CCC1(CS(=O)(=O)O)C(=O)C2=Cc1ccc(C=C2C(=O)C3(CS(=O)(=O)O)CCC2C3(C)C)cc1 |
| Use of | Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) [1] [2]. Properties Name Ecamsule Synonym More Synonyms ecamsule Biological Activity Description Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) [1] [2]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Stefanie Hofer, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244. [2]. DeLeo VA, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103. Chemical & Physical Properties Molecular Formula C28H34O8S2 Exact Mass 562.169495 PSA 159.64000 Index of Refraction 1.631 InChIKey HEAHZSUCFKFERC-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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