CAS Number1893-33-0
SynonymsDipiperal; piperonil; floropipamide; MCN-JR-3345; Dipiperon; Pipamperone; R 3345; Piperonyl; Floropipamid; Propitan; PIPAMPERONE DIHYDROCHLORIDE APPROX. 99; 1'-[4-(4-fluoro-phenyl)-4-oxo-butyl]-octahydro-[1,4']bipyridinyl-4'-carboxylic acid amide; FPA; 1'-[3-(p-fluorobenzoyl)propyl]-[1,4'-bipiperidine]-4'-carboxamide; Dipiperone
Molecular FormulaC21H30O2N3F1
Molecular Weight375.49
Density1.174g/cm3
Boiling Point563.7ºC at 760 mmHg
Melting Point126°C(lit.)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1893-33-0 |
| Catalog No. | 2A-1196457 |
| Chinese Name | 匹泮哌隆 |
| Synonyms | Dipiperal; piperonil; floropipamide; MCN-JR-3345; Dipiperon; Pipamperone; R 3345; Piperonyl; Floropipamid; Propitan; PIPAMPERONE DIHYDROCHLORIDE APPROX. 99; 1'-[4-(4-fluoro-phenyl)-4-oxo-butyl]-octahydro-[1,4']bipyridinyl-4'-carboxylic acid amide; FPA; 1'-[3-(p-fluorobenzoyl)propyl]-[1,4'-bipiperidine]-4'-carboxamide; Dipiperone |
| Molecular Formula | C21H30O2N3F1 |
| Molecular Weight | 375.49 |
| Density | 1.174g/cm3 |
| Boiling Point | 563.7ºC at 760 mmHg |
| Melting Point | 126°C(lit.) |
| Storage Condition | room temperature |
| Application | Pipamperone (Floropipamide; McN-JR 3345; R 3345) is a high-affinity antagonist of the 5-HT2A receptor (pKi=8.2) and the D4 receptor (pKi=8.0). Pipamperone (Floropipamide; McN-JR 3345; R 3345) is a low |
| HTC | 2933399090 |
| PubChem ID | 5514444 |
| MDL Number | MFCD00242979 |
| SMILES | NC(=O)C1(N2CCCCC2)CCN(CCCC(=O)c2ccc(F)cc2)CC1 |
| InChI | InChI=1S/C21H30FN3O2.2ClH/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25;;/h6-9H,1-5,10-16H2,(H2,23,27);2*1H |
| InChI Key | AXKPFOAXAHJUAG-UHFFFAOYSA-N |
| MSDS | msds/198223_1_1893_33_0.pdf |
| Use of | Pipamperone (Floropipamide; McN-JR 3345; R 3345) is a high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) and a low-affinity antagonist of D2 receptor (pKi=6.7)[1]. Properties Name pipamperone Synonym More Synonyms Pipamperone Biological Activity Description Pipamperone (Floropipamide; McN-JR 3345; R 3345) is a high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) and a low-affinity antagonist of D2 receptor (pKi=6.7)[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor 5-HT2A Receptor:8.2 (pKi) 5-HT1 Receptor:5.7 (pKi) D4 receptor:8.0 (pKi) D2 receptor:6.7 (pKi) α1 receptor:7.2 (pKi) References [1]. Erik Buntinx, MD, et al. Selective Serotonergic Properties of Low-Dose Pipamperone May Enhance Antidepressant Effect: Preclinical Evidence. Chemical & Physical Properties Molecular Formula C21H30FN3O2 Exact Mass 375.23200 PSA 66.64000 LogP 3.17050 Index of Refraction 1.556 InChIKey AXKPFOAXAHJUAG-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : (1,4'-Bipiperidine)-4'-carboxamide, 1'-(3-(p-fluorobenzoyl)propyl)- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C21-H30-F-N3-O2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T6NTJ DVZ A- DT6NTJ A3VR DF HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANPBAZ Acta Neurologia et Psychiatrica Belgica. (Brussels, Belgium) V.48-69, 1948-69. For publisher information, see ANUBBR. Volume(issue)/page/year: 61,611,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANPBAZ Acta Neurologia et Psychiatrica Belgica. (Brussels, Belgium) V.48-69, 1948-69. For publisher information, see ANUBBR. Volume(issue)/page/year: 61,611,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,188,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - toxic psychosis REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 15,485,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,188,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,188,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 10-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 28,621,1981 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 1,203,1974 TOXICOLOGY REVIEW MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 4(2),199,1967 Safety Information Hazard Codes Xn Risk Phrases 22 WGK Germany 1 HS Code 2933399090 Synthetic Route Total: 1 Page 4-[4-(1-Piperid... CAS#:39633-82-4 4-Chloro-p-fluo... CAS#:3874-54-2 Pipamperone CAS#:1893-33-0 Literature: Leyva-Perez, Antonio; Cabrero-Antonino, Jose R.; Rubio-Marques, Paula; Al-Resayes, Saud I.; Corma, Avelino ACS Catalysis, 2014 , vol. 4, # 3 p. 722 - 731 1-(4-chlorobut-... CAS#:1183278-95-6 Pipamperone CAS#:1893-33-0 Literature: Leyva-Perez, Antonio; Cabrero-Antonino, Jose R.; Rubio-Marques, Paula; Al-Resayes, Saud I.; Corma, Avelino ACS Catalysis, 2014 , vol. 4, # 3 p. 722 - 731 Precursor & DownStream Precursor 3 CAS#:39633-82-4 4-[4-(1-Piperid... CAS#:3874-54-2 4-Chloro-p-fluo... CAS#:1183278-95-6 1-(4-chlorobut-... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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