CAS Number4338-47-0
SynonymsN-(2-Furylmethyl)-9-pentofuranosyl-9H-purin-6-amine; furfuryladenosine; EINECS 224-389-3; 6-Furfurylaminopurine riboside (N6-(2-Furanylmethyl)adenosine; Kinetin-9-riboside; MFCD00037987; n-furfuryl-adenosin; Ribosylkinetin; N-Furfuryladenosine
Molecular FormulaC15H17N5O5
Molecular Weight347.33
Purity≥98 (HPLC)%
Density1.8±0.1 g/cm3
Boiling Point683.7±65.0 °C at 760 mmHg
Melting Point152-154ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4338-47-0 |
| Catalog No. | 2A-1196163 |
| Chinese Name | 激动素核苷 |
| Synonyms | N-(2-Furylmethyl)-9-pentofuranosyl-9H-purin-6-amine; furfuryladenosine; EINECS 224-389-3; 6-Furfurylaminopurine riboside (N6-(2-Furanylmethyl)adenosine; Kinetin-9-riboside; MFCD00037987; n-furfuryl-adenosin; Ribosylkinetin; N-Furfuryladenosine |
| Molecular Formula | C15H17N5O5 |
| Molecular Weight | 347.33 |
| Purity | ≥98 (HPLC) |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 683.7±65.0 °C at 760 mmHg |
| Melting Point | 152-154ºC |
| Appearance | powder |
| Storage Condition | It should be sealed and stored in a dry place at 4 |
| Application | Kinetin riboside is a cytokinin analog that can induce cancer cell death. The IC50 value for inhibiting HCT-15 cell proliferation is 2.5 μM. |
| HTC | 29349990 |
| PubChem ID | 3139582 |
| MDL Number | MFCD00037987 |
| SMILES | O[C@@]1([C@@]([H])([C@]([H])(O[C@@]1([H])N2C=NC3=C2N=CN=C3NCC4=CC=CO4)CO)O)[H] |
| InChI | InChI=1S/C15H17N5O5/c21-5-9-11(22)12(23)15(25-9)20-7-19-10-13(17-6-18-14(10)20)16-4-8-2-1-3-24-8/h1-3,6-7,9,11-12,15,21-23H,4-5H2,(H,16,17,18)/t9-,11-,12-,15-/m1/s1 |
| InChI Key | CAGLGYNQQSIUGX-SDBHATRESA-N |
| NACRES Code | NA.21 |
| UNSPSC | 12352207 |
| Hazard Symbols | transportation |
| MSDS | msds/197908_1_4338_47_0.pdf |
| Bioactivity | Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 μM. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Target IC50: 2.5 μM (HCT-15 cells)[1] In Vitro Kinetin riboside displays antiproliferative and apoptogenic activity against various human cancer cell lines. Kinetin riboside is able to inhibit the proliferation in HCT-15 human colon cancer cells in a dose-dependent manner (IC50=2.5 μM)[1]. Kinetin riboside induces apoptosis in HeLa and mouse melanoma B16F-10 cells. Kinetin riboside disrupts the mitochondrial membrane potential and induces the release of cytochrome c and activation of caspase-3. Bad are up-regulated while Bcl-2 is down-regulated under kinetin riboside exposure[2]. In Vivo Kinetin riboside significantly suppresses tumor growth. The most effective anti-melanoma response is elicited at 40 mg/kg[2]. Cell Assay HeLa and mouse melanoma B16F-10 cells are treated with 5, 10, 20 μM kinetin riboside for 48 h. 15 μL of MTT solution (5 mg/mL) is added to each well and cells are maintained for 4 h at 37°C. Hundred microlitres of solubilizing solution is then added. After an overnight incubation at room temperature, absorbance at 490 nm is measured[2]. Animal Admin Mice: Male C57BL/6 mice are injected B16 F-10 cells. After 5 days for tumor growth, kinetin riboside (10, 20, 40 mg/kg) is injected to tumor mass directly. Drug injection is performed once a 3 days for three times. After third injection of drug, mice are kept for 3 days with no injection and tumor mass is removed from each mouse and weighed[2]. References [1]. Rajabi M, et al. Antiproliferative activity of kinetin riboside on HCT-15 colon cancer cell line. Nucleosides Nucleotides Nucleic Acids. 2012;31(6):474-81. [2]. Choi BH, et al. Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Lett. 2008 Mar 8;261(1):37-45. Chemical & Physical Properties Density 1.8±0.1 g/cm3 Boiling Point 683.7±65.0 °C at 760 mmHg Melting Point 152-154ºC Molecular Formula C15H17N5O5 Molecular Weight 347.326 Flash Point 367.3±34.3 °C Exact Mass 347.122955 PSA 138.69000 LogP 0.20 Vapour Pressure 0.0±2.2 mmHg at 25°C Index of Refraction 1.798 InChIKey CAGLGYNQQSIUGX-SDBHATRESA-N SMILES OCC1OC(n2cnc3c(NCc4ccco4)ncnc32)C(O)C1O Storage condition 2-8°C |
| Use of | Properties Articles10 Name kinetin riboside Synonym More Synonyms Kinetin riboside Biological Activity Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer References [2]. Choi BH, et al. Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Lett. 2008 Mar 8;261(1):37-45. Chemical & Physical Properties Molecular Formula C15H17N5O5 Exact Mass 347.122955 PSA 138.69000 Index of Refraction 1.798 InChIKey CAGLGYNQQSIUGX-SDBHATRESA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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