![Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate) structure, CAS 77544-68-4](/structures/210000/197580_1_77544_68_4.png)
CAS Number77544-68-4
SynonymsEthanol,2-[2-(2-hydroxyethoxy)ethoxy]-,1-(4-methylbenzenesulfonate); 2-(2-(2-Hydroxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate; triethyleneglycol monotosylate; 2,2'-[ethane-1,2-diylbis(oxy)]bis[ethanol] mono(4-methylbenzenesulfonate); p-toluenesulfonic acid 2-(2-(2-hydroxyethoxy)ethoxy)ethoxy ester; Tos-PEG4; HO(C2H4O)3Tos; toluene-4-sulfonic acid 2-[2-(2-hydroxy-ethoxy)ethoxy]ethyl ester; Tos-PEG3
Molecular FormulaC13H20O6S1
Molecular Weight304.36
Density1.234±0.06 g/cm3
Boiling Point460.0±35.0 °C
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 77544-68-4 |
| Catalog No. | 2A-1195854 |
| Chinese Name | 对甲苯磺酸酯-三聚乙二醇 |
| Synonyms | Ethanol,2-[2-(2-hydroxyethoxy)ethoxy]-,1-(4-methylbenzenesulfonate); 2-(2-(2-Hydroxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate; triethyleneglycol monotosylate; 2,2'-[ethane-1,2-diylbis(oxy)]bis[ethanol] mono(4-methylbenzenesulfonate); p-toluenesulfonic acid 2-(2-(2-hydroxyethoxy)ethoxy)ethoxy ester; Tos-PEG4; HO(C2H4O)3Tos; toluene-4-sulfonic acid 2-[2-(2-hydroxy-ethoxy)ethoxy]ethyl ester; Tos-PEG3 |
| Molecular Formula | C13H20O6S1 |
| Molecular Weight | 304.36 |
| Density | 1.234±0.06 g/cm3 |
| Boiling Point | 460.0±35.0 °C |
| Storage Condition | 2-8°C, store in inert gas |
| Application | Tos-PEG3 is a PEG-based PROTAC linker that can be used for PROTAC synthesis. Tos-PEG3 (Structure 1) can be used to synthesize 3'-aminooxy oligonucleotide solid supports. |
| HTC | 2909499000 |
| MDL Number | MFCD18433414 |
| SMILES | Cc1ccc(S(=O)(=O)OCCOCCOCCO)cc1 |
| InChI | InChI=1S/C13H20O6S/c1-12-2-4-13(5-3-12)20(15,16)19-11-10-18-9-8-17-7-6-14/h2-5,14H,6-11H2,1H3 |
| InChI Key | RSUCRUOTLCQWFX-UHFFFAOYSA-N |
| MSDS | msds/197580_1_77544_68_4.pdf |
| Use of | Properties Name 2-[2-(2-Hydroxyethoxy)ethoxy]ethyl 4-methylbenzenesulfonate Synonym More Synonyms Tos-PEG3 Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. References [1]. Noël M, et al. Solid Supports for the Synthesis of 3'-Aminooxy Deoxy- or Ribo-oligonucleotides and Their 3'-Conjugation by Oxime Ligation.J Org Chem. 2019 Nov 15;84(22):14854-14860. Chemical & Physical Properties Molecular Formula C13H20O6S Exact Mass 304.09800 PSA 90.44000 LogP 1.80660 InChIKey RSUCRUOTLCQWFX-UHFFFAOYSA-N Safety Information HS Code 2909499000 Synthetic Route Total: 1 Page Tosyl chloride CAS#:98-59-9 Triethylene glycol CAS#:112-27-6 CAS#:77544-68-4 Literature: Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48 Tosyl chloride CAS#:98-59-9 Triethylene glycol CAS#:112-27-6 CAS#:77544-68-4 Triethylene gly... CAS#:19249-03-7 Literature: Bouzide, Abderrahim; Sauve, Gilles Organic Letters, 2002 , vol. 4, # 14 p. 2329 - 2332 Precursor & DownStream Precursor 2 CAS#:98-59-9 Tosyl chloride CAS#:112-27-6 Triethylene glycol DownStream 10 CAS#:17455-13-9 18-Crown-6 CAS#:2615-15-8 hexaethyleneglycol CAS#:208827-90-1 Propargyl-PEG3-... CAS#:3386-18-3 nonaethylene glycol |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
| Related Products in Industrial Applications | ||
|---|---|---|
| N-(m-hydroxyphenyl)-p-toluenesulphonamide | 1146-43-6 | 2A-1195736 |
| phosphoric acid,2-naphthalenyl diphenyl ester | 18872-49-6 | 2A-1195812 |
| 1,2-Benzenedimethanol, 3-fluoro-6-[(methylsulfonyl)oxy]- | 1879931-88-0 | 2A-1195816 |
| 2-(2-Azidoethoxy)ethanol | 139115-90-5 | 2A-1195826 |
| 1,3-DIBROMOACETONE | 816-39-7 | 2A-1195838 |
| 1-HYDROXY-1-CYCLOHEXANECARBONITRILE | 931-97-5 | 2A-2196004 |
| PRE-DISPERSEDPOLYMERBOUNDJH-S69SILANECOUPLINGAGENT | 2A-2196124 | 2A-2196124 |
| Amino silane Polymer | 2A-2196207 | 2A-2196207 |
| Epoxy silane Polymer | 2A-2196210 | 2A-2196210 |
| Acyloxyvinyl silane polymer | 2A-2196213 | 2A-2196213 |
| Browse all Industrial Applications products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS