| Chemical & Physical Properties | |
|---|---|
| CAS Number | 54197-31-8 |
| Catalog No. | 2A-1195254 |
| Chinese Name | R-(+)-甲基吲唑酮 |
| Synonyms | Indanyloxyacetic acid 94 (R(+)-Methylindazone; IAA-94; Indanyloxyacetic acid; R(+)-IAA-94 |
| Molecular Formula | C17H18Cl2O4 |
| Molecular Weight | 357.23 |
| Purity | ≥98 (HPLC) |
| Density | 1.401g/cm3 |
| Boiling Point | 537.2ºC at 760 mmHg |
| Appearance | solid |
| Storage Condition | Sealed in a cool, dry environment |
| Application | R(_addition_)-IAA-94 is a highly effective chloride channel inhibitor. |
| PubChem ID | 24277844 |
| SMILES | C[C@@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3 |
| InChI | 1S/C17H18Cl2O4/c1-17(10-4-2-3-5-10)7-9-6-11(23-8-12(20)21)14(18)15(19)13(9)16(17)22/h6,10H,2-5,7-8H2,1H3,(H,20,21)/t17-/m1/s1 |
| InChI Key | RNOJGTHBMJBOSP-QGZVFWFLSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/196940_1_54197_31_8.pdf |
| Bioactivity | R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels.IC50 value:Target: IAA-94 has been employed in modulating chloride channel function to probe the dynamics and function of the channels. The high affinity of IAA-94 for the chloride channel has been exploited for isolation and reconstitution of these proteins. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Others References [1]. Landry DW, et al. Epithelial chloride channel. Development of inhibitory ligands. J Gen Physiol. 1987 Dec;90(6):779-98. [2]. Landry DW, et al. Purification and reconstitution of chloride channels from kidney and trachea. Science. 1989 Jun 23;244(4911):1469-72. [3]. Weber-Schürholz S, et al. Indanyloxyacetic acid-sensitive chloride channels from outer membranes of skeletal muscle. J Biol Chem. 1993 Jan 5;268(1):547-51. Chemical & Physical Properties Density 1.401g/cm3 Boiling Point 537.2ºC at 760 mmHg Molecular Formula C17H18Cl2O4 Molecular Weight 357.22800 Flash Point 278.7ºC Exact Mass 356.05800 PSA 63.60000 LogP 4.39210 Index of Refraction 1.597 InChIKey RNOJGTHBMJBOSP-KRWDZBQOSA-N SMILES CC1(C2CCCC2)Cc2cc(OCC(=O)O)c(Cl)c(Cl)c2C1=O |
| Use of | R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels.IC50 value:Target: IAA-94 has been employed in modulating chloride channel function to probe the dynamics and function of the channels. The high affinity of IAA-94 for the chloride channel has been exploited for isolation and reconstitution of these proteins. Properties Articles31 Name 2-[[(2S)-6,7-dichloro-2-cyclopentyl-2-methyl-1-oxo-3H-inden-5-yl]oxy]acetic acid Synonym More Synonyms IAA-94 Biological Activity Description R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels.IC50 value:Target: IAA-94 has been employed in modulating chloride channel function to probe the dynamics and function of the channels. The high affinity of IAA-94 for the chloride channel has been exploited for isolation and reconstitution of these proteins. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Others References [1]. Landry DW, et al. Epithelial chloride channel. Development of inhibitory ligands. J Gen Physiol. 1987 Dec;90(6):779-98. [2]. Landry DW, et al. Purification and reconstitution of chloride channels from kidney and trachea. Science. 1989 Jun 23;244(4911):1469-72. [3]. Weber-Schürholz S, et al. Indanyloxyacetic acid-sensitive chloride channels from outer membranes of skeletal muscle. J Biol Chem. 1993 Jan 5;268(1):547-51. Chemical & Physical Properties Exact Mass 356.05800 PSA 63.60000 LogP 4.39210 Index of Refraction 1.597 InChIKey RNOJGTHBMJBOSP-KRWDZBQOSA-N |
| Transport Info | Product name: IAA-94 |
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