CAS Number1428-95-1
SynonymsHMA; 3-amino-5-azepan-1-yl-6-chloro-pyrazine-2-carboxylic acid carbamimidoylamide; HMA-5; 3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; Hexamethyleneamiloride
Molecular FormulaC12H18O1N7Cl1
Molecular Weight311.77
Density1.63g/cm3
Boiling Point638.2ºC at 760mmHg
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1428-95-1 |
| Catalog No. | 2A-2195227 |
| Chinese Name | 5-(N,N-六亚甲基)阿米洛利 |
| Synonyms | HMA; 3-amino-5-azepan-1-yl-6-chloro-pyrazine-2-carboxylic acid carbamimidoylamide; HMA-5; 3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; Hexamethyleneamiloride |
| Molecular Formula | C12H18O1N7Cl1 |
| Molecular Weight | 311.77 |
| Density | 1.63g/cm3 |
| Boiling Point | 638.2ºC at 760mmHg |
| Storage Condition | 2-8°C |
| Packaging | III |
| Application | 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride), a derivative of amiloride, is also a potent Na+/H+ exchange inhibitor that reduces the intracellular pH (pHi) of leukemia cells and induces t |
| HTC | 2934999090 |
| PubChem ID | 3721421 |
| MDL Number | MFCD04221099 |
| SMILES | NC(N)=NC(=O)c1nc(Cl)c(N2CCCCCC2)nc1N |
| InChI | InChI=1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21) |
| InChI Key | RQQJJXVETXFINY-UHFFFAOYSA-N |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/196911_1_1428_95_1.pdf |
| Use of | Properties Articles43 Name 5-(N,N-hexamethylene)amiloride Synonym More Synonyms 5-(N,N-Hexamethylene)-amiloride Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Na+/H+ exchanger[1] EC50: 3.91 μM (MHV replication), 1.34 μM (HCoV229E replication)[2] References [1]. Rich IN, et al. Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na(+)/H(+) exchanger. Blood. 2000 Feb 15;95(4):1427-34. [2]. Wilson L, et al. Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication. Virology. 2006 Sep 30;353(2):294-306. Epub 2006 Jul 3. Chemical & Physical Properties Exact Mass 311.12600 PSA 136.51000 LogP 2.55300 Index of Refraction 1.742 InChIKey RQQJJXVETXFINY-UHFFFAOYSA-N Safety Information Signal Word Danger Hazard Statements H301-H311-H331 Precautionary Statements P261-P280-P301 + P310-P311 Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges Hazard Codes T RIDADR UN 2811 WGK Germany 3 Packaging Group III Hazard Class 6.1(b) HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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