CAS Number53174-06-4
SynonymsUNII-O763YB84E3; MFCD00180756; (S)-(-)-3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid; (-)-(S)-6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid; (S)-(-)-Trolox; (S)-(-)-Trolox C; (S)-Trolox(TM); (2S)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
Molecular FormulaC14H18O4
Molecular Weight250.29
Purity98%
Density1.219g/cm3
Boiling Point450.3ºC at 760 mmHg
Melting Point160 °C (dec.) (lit.)
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 53174-06-4 |
| Catalog No. | 2A-1194686 |
| Chinese Name | (S)-(-)-6-羟基-2,5,7,8-四甲基色满-2-羧酸 |
| Synonyms | UNII-O763YB84E3; MFCD00180756; (S)-(-)-3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid; (-)-(S)-6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid; (S)-(-)-Trolox; (S)-(-)-Trolox C; (S)-Trolox(TM); (2S)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid |
| Molecular Formula | C14H18O4 |
| Molecular Weight | 250.29 |
| Purity | 98 |
| Density | 1.219g/cm3 |
| Boiling Point | 450.3ºC at 760 mmHg |
| Melting Point | 160 °C (dec.) (lit.) |
| Appearance | solid |
| Storage Condition | Keep receptacles sealed Place in a tight container |
| Application | (S)-Trolox is a water-soluble analog of vitamin E in which the phytate chain is replaced by a carboxyl group. (S)-Trolox is frequently used as a model compound to study structural characterization and |
| HTC | 2932999099 |
| PubChem ID | 24864411 |
| MDL Number | MFCD00180756 |
| SMILES | Cc1c(C)c2O[C@@](C)(CCc2c(C)c1O)C(O)=O |
| InChI | 1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)/t14-/m0/s1 |
| InChI Key | GLEVLJDDWXEYCO-AWEZNQCLSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352005 |
| MSDS | msds/196340_1_53174_06_4.pdf |
| Use of | (S)-Trolox is a water-soluble analogue of vitamin E, in which the phytyl chain is replaced with a carboxyl group. (S)-Trolox is frequently used as a model compound for studies of structural features, as well as a standard for evaluation of antioxidant activity. (S)-Trolox has potent and specific neuroprotective and antioxidant effects[1][2]. Properties Name (2S)-6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid Synonym More Synonyms (S)-Trolox Biological Activity Description (S)-Trolox is a water-soluble analogue of vitamin E, in which the phytyl chain is replaced with a carboxyl group. (S)-Trolox is frequently used as a model compound for studies of structural features, as well as a standard for evaluation of antioxidant activity. (S)-Trolox has potent and specific neuroprotective and antioxidant effects[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vitro The neuroprotective efficacy of antioxidant molecules against iodoacetate (IAA) neurotoxicity in rat cerebellar granule cell (CGC) cultures is investigated. In the absence of MK-801, (S)-Trolox displays marginal neuroprotective effects. In the presence of MK-801 (10 μM), the neuroprotective efficacy of (S)-Trolox is greatly enhanced, giving rise to a recovery in MTT-reductase activity equivalent to 80-100% of control cultures. (S)-Trolox displays EC50 value of 78 μM. The fluorescence increase in IAA-stimulated DCFH-DA-loaded cultures is inhibited in a dose-dependent manner by the antioxidants (S)-Trolox with an IC50 value of 97 μM. The antioxidant (S)-Trolox demonstrate apotent and specific neuroprotective action in an in vitro model of neurodegeneration induced by inhibition of the glycolytic enzyme GAPDH[1]. References [1]. Malcolm CS, et al. Characterization of iodoacetate-mediated neurotoxicity in vitro using primary cultures of rat cerebellar granule cells. Free Radic Biol Med. 2000 Jan 1;28(1):102-7. [2]. Górecki M, et al. Chromane helicity rule--scope and challenges based on an ECD study of various trolox derivatives. Org Biomol Chem. 2014 Apr 14;12(14):2235-54. Chemical & Physical Properties Molecular Formula C14H18O4 Exact Mass 250.12100 PSA 66.76000 LogP 2.48570 Index of Refraction 1.567 InChIKey GLEVLJDDWXEYCO-AWEZNQCLSA-N Safety Information Signal Word Warning Hazard Statements H315-H319-H335 Precautionary Statements P261-P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xi RIDADR NONH for all modes of transport HS Code 2932999099 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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