| Chemical & Physical Properties | |
|---|---|
| CAS Number | 54-06-8 |
| Catalog No. | 2A-1194634 |
| Chinese Name | 肾上腺色素 |
| Synonyms | adrenochrome |
| Molecular Formula | C9H9NO3 |
| Molecular Weight | 179.17 |
| Purity | ≥95 (HPLC) |
| Density | 1.42g/cm3 |
| Boiling Point | 375.1ºC at 760 mmHg |
| Melting Point | 115-120ºC |
| Appearance | powder |
| Storage Condition | The warehouse is ventilated and dried at low tempe |
| Application | Adrenochrome (Adraxone) is the oxidation product of adrenaline. Adrenochrome is a potent constrictor of coronary arteries in the rat heart. Adrenochrome can be used in the study of neurological diseas |
| EINECS | 200-192-8 |
| HTC | 2933990090 |
| PubChem ID | 24891016 |
| MDL Number | MFCD00069732 |
| SMILES | CN1CC(O)C2=CC(=O)C(=O)C=C12 |
| InChI | 1S/C9H9NO3/c1-10-4-9(13)5-2-7(11)8(12)3-6(5)10/h2-3,9,13H,4H2,1H3 |
| InChI Key | RPHLQSHHTJORHI-UHFFFAOYSA-N |
| NACRES Code | NA.47 |
| UNSPSC | 12171500 |
| Hazard Symbols | transportation |
| MSDS | msds/196315_1_54_06_8.pdf |
| Bioactivity | Adrenochrome (Adraxone) is an oxidation product of Epinephrine. Adrenochrome is a potent coronary constricting agent in the rat heart. Adrenochrome can be used for neurological disorder research[1][2][3]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vitro Adrenochrome decreases microsomal calcium binding, calcium uptake and Ca2+-stimulated Mg2+-dependent ATPase activities. The inhibitory effect of Adrenochrome on microsomal calcium uptake activity of the isolated membrane is independent of pH (6.0-8.0), calcium concentrations (10-200 μM), protein concentration (0.02-0.10 mg/mL), temperature (25-37 degrees C) and incubation time (2-30 min)[2]. In Vivo In isolated rat hearts, concentrations of Adrenochrome from 1 to 1000 ng/mL increases coronary pressure in a dose- and time-dependent manner. Furthermore, the degree of constriction by Adrenochrome is dependent on the CaCl2 concentration in the perfusion medium[1]. References [1]. M Karmazyn,, et al. Adrenochrome-induced coronary artery constriction in the rat heart. J Pharmacol Exp Ther. 1981 Oct;219(1):225-30. [2]. S Takeo,et al. Effects of adrenochrome on calcium accumulating and adenosine triphosphatase activities of the rat heart microsomes. J Pharmacol Exp Ther. 1980 Sep;214(3):688-93. [3]. Koji Ueda, et al. Catecholamine oxidation-mediated transcriptional inhibition in Mn neurotoxicity. J Toxicol Sci. 2020;45(10):619-624. Chemical & Physical Properties Density 1.42g/cm3 Boiling Point 375.1ºC at 760 mmHg Melting Point 115-120ºC Molecular Formula C9H9NO3 Molecular Weight 179.17300 Flash Point 180.7ºC Exact Mass 179.05800 PSA 57.61000 Index of Refraction 1.63 InChIKey RPHLQSHHTJORHI-UHFFFAOYSA-N SMILES CN1CC(O)C2=CC(=O)C(=O)C=C21 |
| Use of | Adrenochrome (Adraxone) is an oxidation product of Epinephrine. Adrenochrome is a potent coronary constricting agent in the rat heart. Adrenochrome can be used for neurological disorder research[1][2][3]. Properties Articles29 Name 3-Hydroxy-1-methyl-5,6-indolinedione Synonym More Synonyms ADRENOCHROME Biological Activity Description Adrenochrome (Adraxone) is an oxidation product of Epinephrine. Adrenochrome is a potent coronary constricting agent in the rat heart. Adrenochrome can be used for neurological disorder research[1][2][3]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. M Karmazyn,, et al. Adrenochrome-induced coronary artery constriction in the rat heart. J Pharmacol Exp Ther. 1981 Oct;219(1):225-30. [2]. S Takeo,et al. Effects of adrenochrome on calcium accumulating and adenosine triphosphatase activities of the rat heart microsomes. J Pharmacol Exp Ther. 1980 Sep;214(3):688-93. [3]. Koji Ueda, et al. Catecholamine oxidation-mediated transcriptional inhibition in Mn neurotoxicity. J Toxicol Sci. 2020;45(10):619-624. Chemical & Physical Properties Molecular Formula C9H9NO3 Exact Mass 179.05800 PSA 57.61000 Index of Refraction 1.63 InChIKey RPHLQSHHTJORHI-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available The company is not responsible for any damage caused by any operation or contact with the above products. For more terms of use, see invoice or package The reverse side of the mounting strip. |
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