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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 21516-68-7 |
| Catalog No. | 2A-2193766 |
| Chinese Name | 红曲素 |
| Synonyms | Monascoflavin; Monascin; monascusone B |
| Molecular Formula | C21H26O5 |
| Molecular Weight | 358.43 |
| Purity | ≥97.0 (HPLC) |
| Appearance | solid |
| Storage Condition | 2-8°C |
| Application | Monascin is an azochrome that can be extracted from red yeast rice. It is orally active and has anti-tumor and anti-inflammatory activities. Monascin also inhibits NOR activation. |
| PubChem ID | 329757837 |
| MDL Number | MFCD09260177 |
| SMILES | CCCCCC(=O)[C@@H]1[C@H]2CC3=C(COC(\C=C\C)=C3)C(=O)[C@]2(C)OC1=O |
| InChI | 1S/C21H26O5/c1-4-6-7-9-17(22)18-16-11-13-10-14(8-5-2)25-12-15(13)19(23)21(16,3)26-20(18)24/h5,8,10,16,18H,4,6-7,9,11-12H2,1-3H3/b8-5+/t16-,18+,21-/m1/s1 |
| InChI Key | XXKNHBAFFJINCK-RVEJDSBJSA-N |
| Beilstein/REAXYS | 51355 |
| NACRES Code | NA.47 |
| UNSPSC | 12352200 |
| MSDS | msds/195370_1_21516_68_7.pdf |
| Bioactivity | Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor)[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology In Vivo Monascin (0.0025% in drinking water; mice) appears effective for the inhibition of UVB-initiated carcinogenesis on mouse skin[1]. Animal Model: SENCAR mouse using a UVB irradiation as an initiator and TPA as a promoter[1]. Dosage: 0.0025% in drinking water. Administration: Orally daily for 2 weeks in drinking water. Result: Reduced the number of the papillomas. References [1]. Akihisa T, et al. Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice). Chem Biodivers. 2005 Oct;2(10):1305-9. [2]. Lee CL, et al. Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent--monacolin K and antiinflammation agent--monascin. Appl Microbiol Biotechnol. 2006 Oct;72(6):1254-62. Chemical & Physical Properties Molecular Formula C21H26O5 Molecular Weight 358.42800 Exact Mass 358.17800 PSA 69.67000 LogP 3.44330 InChIKey XXKNHBAFFJINCK-RVEJDSBJSA-N SMILES CC=CC1=CC2=C(CO1)C(=O)C1(C)OC(=O)C(C(=O)CCCCC)C1C2 Storage condition 2-8°C |
| Use of | Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor)[1][2]. Properties Name monascin Synonym More Synonyms monascin Biological Activity Description Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor)[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology In Vivo Monascin (0.0025% in drinking water; mice) appears effective for the inhibition of UVB-initiated carcinogenesis on mouse skin[1]. Animal Model: SENCAR mouse using a UVB irradiation as an initiator and TPA as a promoter[1]. Dosage: 0.0025% in drinking water. Administration: Orally daily for 2 weeks in drinking water. Result: Reduced the number of the papillomas. References [1]. Akihisa T, et al. Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice). Chem Biodivers. 2005 Oct;2(10):1305-9. [2]. Lee CL, et al. Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent--monacolin K and antiinflammation agent--monascin. Appl Microbiol Biotechnol. 2006 Oct;72(6):1254-62. Chemical & Physical Properties Molecular Formula C21H26O5 Exact Mass 358.17800 PSA 69.67000 LogP 3.44330 InChIKey XXKNHBAFFJINCK-RVEJDSBJSA-N |
| Transport Info | Product name: Red yeast rice |
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