CAS Number483-15-8
Synonyms9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline; Dihydroberbine; 9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline; Dihydroberberine
Molecular FormulaC20H19NO4
Molecular Weight337.37
Purity≥90.0 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point557.8±50.0 °C at 760 mmHg
Melting Point223-224ºC (dec.)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 483-15-8 |
| Catalog No. | 2A-1193266 |
| Chinese Name | 二氢小檗碱 |
| Synonyms | 9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline; Dihydroberbine; 9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline; Dihydroberberine |
| Molecular Formula | C20H19NO4 |
| Molecular Weight | 337.37 |
| Purity | ≥90.0 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 557.8±50.0 °C at 760 mmHg |
| Melting Point | 223-224ºC (dec.) |
| Storage Condition | 2-8C |
| Application | Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine has anti |
| HTC | 2934999090 |
| MDL Number | MFCD00022312 |
| SMILES | N21CCc3c(cc5c(c3)OCO5)C2=Cc4c(c(c(cc4)OC)OC)C1 |
| InChI | 1S/C20H19NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-9H,5-6,10-11H2,1-2H3 |
| InChI Key | FZAGOOYMTPGPGF-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/194841_1_483_15_8.pdf |
| Use of | Dihydroberberine inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces heat shock protein 90 (Hsp90) expression and its interaction with hERG. Dihydroberberine has anti-inflammatory, anti-atherosclerotic, hypolipidemic and antitumor activities[1]. Properties Name 9,10-Dimethoxy-6,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline Synonym More Synonyms Dihydroberberine Biological Activity Description Dihydroberberine inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces heat shock protein 90 (Hsp90) expression and its interaction with hERG. Dihydroberberine has anti-inflammatory, anti-atherosclerotic, hypolipidemic and antitumor activities[1]. Related Catalog Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> HSP Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel References Chemical & Physical Properties Molecular Formula C20H19NO4 Exact Mass 337.131409 PSA 40.16000 Index of Refraction 1.679 InChIKey FZAGOOYMTPGPGF-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Berbine, 13,13a-didehydro-9,10-dimethoxy-2,3-(methylenedioxy)- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C20-H19-N-O4 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T G6 E6 B665 EN SO UO FH TH&&T&&J HO1 IO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 15,486,1981 Safety Information HS Code 2934999090 Synthetic Route Berberine hydro... Dihydroberberin... Literature: HANWHA CHEMICAL CORPORATION Patent: EP1073655 B1, 2004 ; Location in patent: Page 10 ; 7,8-dimethoxy-2... 113557-43-0 Dihydroberberin... Literature: Hanaoka, Miyoji; Hirasawa, Taeko; Cho, Won Jea; Yasuda, Shingo Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 3 p. 399 - 404 Berberinol 10134-52-8 Dihydroberberin... Literature: Bose Journal of the Indian Chemical Society, 1955 , vol. 32, p. 450,453, 454 Full Text Show Details Schmid; Karrer Helvetica Chimica Acta, 1949 , vol. 32, p. 960,965 Precursor & DownStream Precursor 10 CAS#:633-65-8 Berberine hydro... CAS#:113557-43-0 7,8-dimethoxy-2... CAS#:10134-52-8 Berberinol CAS#:522-97-4 Tetrahydroberberine DownStream 7 CAS#:633-65-8 Berberine hydro... CAS#:62595-72-6 berberinephenol... CAS#:10134-52-8 Berberinol CAS#:21796-14-5 1,3-Dioxolo[4,5... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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