CAS Number85416-73-5
Synonyms(4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; S2127_Selleck; (4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one; 1oyn; S- (+)-Rolipram; S-(+)-Rolipram; (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; S-(+)-4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidinone; (S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one; (-)-rolipram; 1xn0; (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; (+)-rolipram; (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; (S)-(+)-Rolipram
Molecular FormulaC16H21NO3
Molecular Weight275.35
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point472.7±45.0 °C at 760 mmHg
Melting Point133-136ºC
AppearanceSolid;White to Almost white powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 85416-73-5 |
| Catalog No. | 2A-1192632 |
| Chinese Name | (S)-(+)-咯利普兰 |
| Synonyms | (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; S2127_Selleck; (4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one; 1oyn; S- (+)-Rolipram; S-(+)-Rolipram; (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; S-(+)-4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidinone; (S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one; (-)-rolipram; 1xn0; (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; (+)-rolipram; (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; (S)-(+)-Rolipram |
| Molecular Formula | C16H21NO3 |
| Molecular Weight | 275.35 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 472.7±45.0 °C at 760 mmHg |
| Melting Point | 133-136ºC |
| Appearance | Solid;White to Almost white powder to crystal |
| Storage Condition | Store at RT |
| Application | (S)-(+)-Rolipram is a cAMP-specific PDE4 inhibitor with anti-inflammatory activity and is less active than its R-enantiomer. |
| HTC | 2933790090 |
| MDL Number | C16H21NO3 |
| SMILES | COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1 |
| InChI Key | HJORMJIFDVBMOB-GFCCVEGCSA-N |
| Use of | Properties Name (+)-rolipram Synonym More Synonyms S-(+)-Rolipram Biological Activity Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology References [1]. Griswold, D.E., et al., Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation, 1993. 17(3): p. 333-44. [2]. Zhu, J., E. Mix, and B. Winblad, The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev, 2001. 7(4): p. 387-98. [4]. Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36. Chemical & Physical Properties Molecular Formula C16H21NO3 Exact Mass 275.152130 PSA 47.56000 Index of Refraction 1.552 InChIKey HJORMJIFDVBMOB-GFCCVEGCSA-N Storage condition Store at RT Safety Information HS Code 2933790090 Synthetic Route (S)-methyl 3-(3... 1001860-35-0 S-(+)-Rolipram 85416-73-5 Literature: Palomo, Claudio; Landa, Aitor; Mielgo, Antonia; Oiarbide, Mikel; Puente, Angel; Vera, Silvia Angewandte Chemie - International Edition, 2007 , vol. 46, # 44 p. 8431 - 8435 959799-63-4 S-(+)-Rolipram 85416-73-5 Literature: Han, Fuzhong; Chen, Jun; Zhang, Xiangyang; Liu, Jibing; Cun, Linfeng; Zhu, Jin; Deng, Jingen; Liao, Jian Tetrahedron Letters, 2011 , vol. 52, # 7 p. 830 - 833 (S)-S-benzyl 3-... 1259130-31-8 S-(+)-Rolipram 85416-73-5 Literature: Furutachi, Makoto; Mouri, Shinsuke; Matsunaga, Shigeki; Shibasaki, Masakatsu Chemistry - An Asian Journal, 2010 , vol. 5, # 11 p. 2351 - 2354 Precursor & DownStream Precursor 5 CAS#:1001860-35-0 (S)-methyl 3-(3... CAS#:137-43-9 Bromocyclopentane CAS#:67387-76-2 3-(Cyclopentylo... CAS#:621-59-0 Isovanillin DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 9.0% Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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