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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > 2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride
2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride structure, CAS 406209-26-5

2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile hydrochloride

CAS Number406209-26-5

Synonyms2-Amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(piperidin-4-yl)nicotinonitrile hydrochloride; CS-0283; ACHP (Hydrochloride)

Molecular FormulaC21H25O2N4Cl1

Molecular Weight400.91

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Cat. No.: 2A-1191895 Purity:
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Quality Control of [ 406209-26-5 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number406209-26-5
Catalog No.2A-1191895
Chinese NameACHP盐酸盐
Synonyms2-Amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(piperidin-4-yl)nicotinonitrile hydrochloride; CS-0283; ACHP (Hydrochloride)
Molecular FormulaC21H25O2N4Cl1
Molecular Weight400.91
Storage Condition-20°C, sealed, dry
ApplicationACHP Hydrochloride is a potent, selective inhibitor of IKK-β with an IC50 of 8.5 nM.
HTC2933399090
PubChem ID152258438
MDL NumberMFCD22124458
InChIInChI=1S/C21H24N4O2.ClH/c22-11-16-15(14-6-8-24-9-7-14)10-17(25-21(16)23)20-18(26)2-1-3-19(20)27-12-13-4-5-13;/h1-3,10,13-14,24,26H,4-9,12H2,(H2,23,25);1H
InChI KeyQVYAMWAKDKEKMM-UHFFFAOYSA-N
Use ofACHP Hydrochloride is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM. Properties Name (6E)-2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile hydrochloride Synonym More Synonyms ACHP (Hydrochloride) Biological Activity Description ACHP Hydrochloride is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM. Related Catalog Signaling Pathways >> NF-κB >> IKK Research Areas >> Inflammation/Immunology IKK-β:8.5 nM (IC50) IKK-α:250 nM (IC50) References [2]. Sanda T, et al. Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor. Leukemia. 2006 Apr;20(4):590-8. Chemical & Physical Properties Exact Mass 400.16700 PSA 104.92000 LogP 4.22478 Safety Information HS Code 2933399090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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