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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > N-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamidehydrochloride
N-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamidehydrochloride structure, CAS 926023-82-7

N-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamidehydrochloride

CAS Number926023-82-7

Synonyms

Molecular FormulaC23H27O2N2Cl1S1

Molecular Weight431

Purity

Density

Boiling Point

Melting Point

Flash Point

Appearance

EINECS

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Cat. No.: 2A-1191286 Purity:
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Quality Control of [ 926023-82-7 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number926023-82-7
Catalog No.2A-1191286
Chinese NameAMTB hydrochloride
Molecular FormulaC23H27O2N2Cl1S1
Molecular Weight431
Storage Condition-20°C, sealed, dry
ApplicationAMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC50 of 6.23. AMTB hydrochloride can be used in the study of overac
PubChem ID24741800
MDL NumberMFCD18086917
SMILESCc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1.Cl
InChIInChI=1S/C23H26N2O2S.ClH/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20;/h2-5,7-11,14-15H,6,12-13,16-17,24H2,1H3;1H
InChI KeyUDXGBANGPYONOK-UHFFFAOYSA-N
Hazard Symbolstransportation
BioactivityAMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC50 of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels (NaV)[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer Research Areas >> Neurological Disease In Vitro AMTB hydrochloride blocks veratridine-induced membrane potential changes at each NaV1 isoform (pIC50s ranging 4.83-5.69 for NaV1.1- NaV1.8)[2]. AMTB hydrochloride decreases viable cell number in MDA-MB-231 and SK-BR-3 breast cancer cell lines (30 and 100 μM), and also reduces the migration of MDA-MB-231 cells (30 μM)[2]. In Vivo In the anesthetized rat, AMTB (3 mg/kg; intravenous) hydrochloride decreases the frequency of volume-induced bladder contractions, without reducing the amplitude of contraction[1]. References [1]. Lashinger ES, et al. AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am J Physiol Renal Physiol. 2008;295(3):F803-F810. [2]. Yapa KTDS, et al. Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels. Life Sci. 2018;198:128-135. Chemical & Physical Properties Molecular Formula C23H27ClN2O2S Molecular Weight 430.99100 Exact Mass 430.14800 PSA 83.80000 LogP 6.12900 InChIKey UDXGBANGPYONOK-UHFFFAOYSA-N SMILES Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1.Cl
Use ofProperties Name N-(3-Aminopropyl)-2-[(3-methylbenzyl)oxy]-N-(2-thienylmethyl)benz amide hydrochloride (1:1) AMTB hydrochloride Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer Research Areas >> Neurological Disease References [2]. Yapa KTDS, et al. Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels. Life Sci. 2018;198:128-135. Chemical & Physical Properties Exact Mass 430.14800 PSA 83.80000 LogP 6.12900 InChIKey UDXGBANGPYONOK-UHFFFAOYSA-N
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MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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