CAS Number68077-27-0
Synonyms1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride; Norfloxacinum; Chibroxin; Norfloxacin hydrochloride; Noroxin; Norfloxacino; Baccidal; Sebercim; Norfloxacine; Norfloxacin (hydrochloride)
Molecular FormulaC16H19ClFN3O3
Molecular Weight319.33
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 68077-27-0 |
| Catalog No. | 2A-1191069 |
| Chinese Name | 盐酸诺氟沙星 |
| Synonyms | 1-ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride; Norfloxacinum; Chibroxin; Norfloxacin hydrochloride; Noroxin; Norfloxacino; Baccidal; Sebercim; Norfloxacine; Norfloxacin (hydrochloride) |
| Molecular Formula | C16H19ClFN3O3 |
| Molecular Weight | 319.33 |
| Storage Condition | 2-8℃ |
| Application | Norfloxacin is a broad-spectrum antibiotic that inhibits Gram-positive and -negative bacteria by binding to DNA gyrase. |
| HTC | 2933499090 |
| PubChem ID | 31505480 |
| SMILES | CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)cc21.Cl |
| InChI | InChI=1S/C16H18FN3O3.ClH/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20;/h7-9,18H,2-6H2,1H3,(H,22,23);1H |
| InChI Key | JJWDELPVPRCLQN-UHFFFAOYSA-N |
| Use of | Norfloxacin hydrochloride is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.Target: DNA gyrase; AntibacterialNorfloxacin is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Norfloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.There are currently three approved uses in the adult population (one of which is restricted) and the other ineffective due to bacterial resistance. Chibroxin (ophthalmic) is approved for use in children older than one year of age.Norfloxacin is associated with a number of rare serious adverse reactions as well as spontaneous tendon ruptures and irreversible peripheral neuropathy. Tendon problems may manifest long after therapy had been completed and in severe cases may result in lifelong disabilities. Hepatoxicity resulting in fatalities has also been reported with the use of norfloxacin. Properties Name 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid Synonym More Synonyms Norfloxacin hydrochloride Biological Activity Description Norfloxacin hydrochloride is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.Target: DNA gyrase; AntibacterialNorfloxacin is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Norfloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.There are currently three approved uses in the adult population (one of which is restricted) and the other ineffective due to bacterial resistance. Chibroxin (ophthalmic) is approved for use in children older than one year of age.Norfloxacin is associated with a number of rare serious adverse reactions as well as spontaneous tendon ruptures and irreversible peripheral neuropathy. Tendon problems may manifest long after therapy had been completed and in severe cases may result in lifelong disabilities. Hepatoxicity resulting in fatalities has also been reported with the use of norfloxacin. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Natural Products >> Alkaloid References [1]. Nelson JM, et al. Fluoroquinolone-resistant Campylobacter species and the withdrawal of fluoroquinolones from use in poultry: a public health success story. Clin Infect Dis. 2007 Apr 1;44(7):977-80. Epub 2007 Feb 14. [2]. Padeiskaia EN. Norfloxacin: more than 20 years of clinical use, the results and place among fluoroquinolones in modern chemotherapy for infections. Antibiot Khimioter. 2003;48(9):28-36. [3]. Rafalsky V, et al. Quinolones for uncomplicated acute cystitis in women. Cochrane Database Syst Rev. 2006 Jul 19;(3):CD003597. Chemical & Physical Properties PSA 74.57000 LogP 1.66210 InChIKey JJWDELPVPRCLQN-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information Hazard Codes F,C Risk Phrases R11 HS Code 2933499090 Synthetic Route Total: 1 Page Piperazine CAS#:110-85-0 7-Chloro-1-ethy... CAS#:68077-26-9 7-chloro-1-ethy... CAS#:75001-85-3 Norfloxacin hyd... CAS#:68077-27-0 Literature: Heravi, Majid M.; Oskooie, Hossein A.; Motamedi, Radineh; Ghassemzadeh, Mitra Heterocyclic Communications, 2005 , vol. 11, # 5 p. 423 - 426 Precursor & DownStream Precursor 2 CAS#:110-85-0 Piperazine CAS#:68077-26-9 7-Chloro-1-ethy... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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