CAS Number5169-78-8
Synonyms3-(di-thiophen-2-yl-methylene)-1-methyl-piperidine; Bitiodin; Asverin; (1-Methyl-3-piperidylidene)di(2-thienyl)methane; Tipepidine [INN:DCF]; Tipepidine; 3-(Di-[2]thienyl-methylen)-1-methyl-piperidin; Tipepidina [INN-Spanish]; Tipedine; Tipepidinum [INN-Latin]; (1-Methyl-3-piperidyliden)di-2-thienylmethan-embonat; CR/662; AT 327; 3-(di-[2]thienyl-methylene)-1-methyl-piperidine
Molecular FormulaC15H18N1Cl1S2
Molecular Weight311.9
Density1.1947 (rough estimate)
Boiling Pointbp4-5 178-184°
Melting Point64-65°
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5169-78-8 |
| Catalog No. | 2A-1190994 |
| Chinese Name | 替培啶 |
| Synonyms | 3-(di-thiophen-2-yl-methylene)-1-methyl-piperidine; Bitiodin; Asverin; (1-Methyl-3-piperidylidene)di(2-thienyl)methane; Tipepidine [INN:DCF]; Tipepidine; 3-(Di-[2]thienyl-methylen)-1-methyl-piperidin; Tipepidina [INN-Spanish]; Tipedine; Tipepidinum [INN-Latin]; (1-Methyl-3-piperidyliden)di-2-thienylmethan-embonat; CR/662; AT 327; 3-(di-[2]thienyl-methylene)-1-methyl-piperidine |
| Molecular Formula | C15H18N1Cl1S2 |
| Molecular Weight | 311.9 |
| Density | 1.1947 (rough estimate) |
| Boiling Point | bp4-5 178-184° |
| Melting Point | 64-65° |
| Storage Condition | The warehouse is ventilated and dried at low tempe |
| Application | Tipidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK current (IDA(GIRK)), with an IC50 of 7.0 μM. Tipidine subsequently activates VTA dopamine neurons [1]. Tipidine is a non-narcotic a |
| HTC | 2934999090 |
| PubChem ID | 5653395 |
| MDL Number | MFCD22199332 |
| SMILES | CN1CCCC(=C(c2cccs2)c2cccs2)C1 |
| InChI | InChI=1S/C15H17NS2.C6H8O7/c1-16-8-2-5-12(11-16)15(13-6-3-9-17-13)14-7-4-10-18-14;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-4,6-7,9-10H,2,5,8,11H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12) |
| InChI Key | JWIXXNLOKOAAQT-UHFFFAOYSA-N |
| Use of | Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron[1]. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect[2]. Properties Name 3-(dithiophen-2-ylmethylidene)-1-methylpiperidine Synonym More Synonyms tipepidine Biological Activity Description Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron[1]. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect[2]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel IC50: 7.0 μM (dopamine D2 receptor)[1] References [1]. Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current. Neuroscience. 2013 Nov 12;252:24-34. [2]. Kawaura K, et al. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Behav Brain Res. 2016 Apr 1;302:269-78. Chemical & Physical Properties Molecular Formula C15H17NS2 Exact Mass 275.08000 PSA 59.72000 LogP 4.27500 Index of Refraction 1.5300 (estimate) InChIKey JWIXXNLOKOAAQT-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Piperidine, 3-(di-2-thienylmethylene)-1-methyl- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C15-H17-N-S2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1490,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1490,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS Behavioral - excitement Lungs, Thorax, or Respiration - other changes REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 10,1482,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1490,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Behavioral - food intake (animal) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959 Safety Information HS Code 2934999090 Synthetic Route Total: 1 Page (1-methyl-piper... CAS#:5166-68-7 tipepidine CAS#:5169-78-8 Literature: Okumura et al. Ann. Rep. Tanabe pharm. Res.Chem.Abstr., 1958 , vol. 3, # 2 p. 30,32 Ann. Rep. Tanabe pharm. Res.Chem.Abstr., 1959 , p. 10214 Bromothiophene CAS#:1003-09-4 Methyl 1-methyl... CAS#:1690-72-8 tipepidine CAS#:5169-78-8 Literature: Kawazu; Kanno; Saito; Tamaki Journal of medicinal chemistry, 1972 , vol. 15, # 9 p. 914 - 918 Precursor & DownStream Precursor 3 CAS#:5166-68-7 (1-methyl-piper... CAS#:1003-09-4 Bromothiophene CAS#:1690-72-8 Methyl 1-methyl... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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