CAS Number1056634-68-4
SynonymsN-(Cyanomethyl)-4-(2-((4-morpholinophenyl)-amino)pyrimidin-4-yl)benzamide; N-(Cyanomethyl)-4-(2-{[4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)benzamide; Momelotinib; CYT387; CYT-387
Molecular FormulaC23H22O2N6
Molecular Weight414.47
Density1.3±0.1 g/cm3
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1056634-68-4 |
| Catalog No. | 2A-1190776 |
| Chinese Name | Momelotinib |
| Synonyms | N-(Cyanomethyl)-4-(2-((4-morpholinophenyl)-amino)pyrimidin-4-yl)benzamide; N-(Cyanomethyl)-4-(2-{[4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)benzamide; Momelotinib; CYT387; CYT-387 |
| Molecular Formula | C23H22O2N6 |
| Molecular Weight | 414.47 |
| Density | 1.3±0.1 g/cm3 |
| Storage Condition | Room temperature, dry, sealed |
| Application | Momelotinib (CYT387) is an ATP-competitive JAK1/JAK2 inhibitor with IC50 values of 11 nM/18 nM respectively, which is about 10 times more selective for JAK3. |
| HTC | 2934999090 |
| PubChem ID | 56399705 |
| MDL Number | MFCD16038899 |
| SMILES | N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 |
| InChI | InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28) |
| InChI Key | ZVHNDZWQTBEVRY-UHFFFAOYSA-N |
| Use of | Properties Name N-(Cyanomethyl)-4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzamide Synonym More Synonyms CYT387 Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Cancer JAK1:11 nM (IC50) JAK2:18 nM (IC50) JAK3:155 nM (IC50) In Vivo In a murine MPN model, Momelotinib (CYT387) normalizes white cell counts, hematocrit, spleen size, and restores physiologic levels of inflammatory cytokines[3]. Kinase Assay Glutathione-S-transferase (GST)-tagged JAK kinase domains expressed in insect cells are purified before use in a peptide substrate phosphorylation assay. Assays are carried out in 384-well optiplates using an Alphascreen Protein Tyrosine Kinase P100 detection kit and a PerkinElmer Fusion Alpha instrument. References [2]. Monaghan KA, et al. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells. Leukemia, 2011, 25(12), 1891-1899. [3]. Tyner JW, et al. CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms. Blood, 2010, 115(25), 5232-5240. Chemical & Physical Properties Molecular Formula C23H22N6O2 Exact Mass 414.180420 PSA 103.17000 Index of Refraction 1.646 InChIKey ZVHNDZWQTBEVRY-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 2934999090 Synthetic Route Total: 1 Page 4-(2-(4-Morphol... CAS#:945749-71-3 Aminoacetonitri... CAS#:6011-14-9 CAS#:1056634-68-4 Precursor & DownStream Precursor 2 CAS#:945749-71-3 4-(2-(4-Morphol... CAS#:6011-14-9 Aminoacetonitri... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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