CAS Number5631-70-9
Synonyms4',5,7-Trimethyl-apigenin; 4',5,7-Trimethoxyflavone; Apigenin trimethyl ether; 5,7,4'-Trimethylapigenin; apigenin 4',5,7-trimethyl ether; Trimethylapigenin
Molecular FormulaC18H16O5
Molecular Weight312.32
Density1.242g/cm3
Boiling Point506.5ºC at 760mmHg
Melting Point158-160ºC (dec.)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5631-70-9 |
| Catalog No. | 2A-1190674 |
| Chinese Name | 三甲基芹菜素 |
| Synonyms | 4',5,7-Trimethyl-apigenin; 4',5,7-Trimethoxyflavone; Apigenin trimethyl ether; 5,7,4'-Trimethylapigenin; apigenin 4',5,7-trimethyl ether; Trimethylapigenin |
| Molecular Formula | C18H16O5 |
| Molecular Weight | 312.32 |
| Density | 1.242g/cm3 |
| Boiling Point | 506.5ºC at 760mmHg |
| Melting Point | 158-160ºC (dec.) |
| Storage Condition | room temperature |
| Application | 5,7,4'-Trimethoxyflavone was isolated from Kaempferia parviflora (KP), a famous medicinal plant in Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, which is manifested by increased sub-G1 phase, |
| HTC | 2932999099 |
| PubChem ID | 3277742 |
| MDL Number | MFCD00017636 |
| SMILES | COc1ccc(-c2cc(=O)c3c(OC)cc(OC)cc3o2)cc1 |
| InChI | InChI=1S/C18H16O5/c1-20-12-6-4-11(5-7-12)15-10-14(19)18-16(22-3)8-13(21-2)9-17(18)23-15/h4-10H,1-3H3 |
| InChI Key | ZXJJBDHPUHUUHD-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Use of | 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner[1]. Properties Name 5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one Synonym More Synonyms Trimethylapigenin Biological Activity Description 5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Cell Cycle/DNA Damage >> PARP References [1]. Kim H, et al. Induction of ER Stress-Mediated Apoptosis by the Major Component 5,7,4'-TrimethoxyflavoneIsolated from Kaempferia parviflora Tea Infusion. Nutr Cancer. 2018 Aug-Sep;70(6):984-996. Chemical & Physical Properties Molecular Formula C18H16O5 Exact Mass 312.10000 PSA 57.90000 LogP 3.48580 Index of Refraction 1.585 InChIKey ZXJJBDHPUHUUHD-UHFFFAOYSA-N Safety Information HS Code 2932999099 Synthetic Route methyl iodide Trimethylapigen... Literature: Vins, Petr; Vermachova, Martina; Drasar, Pavel; Del Barrio, Melisa; Jarne, Carmen; Cebolla, Vicente L.; De Cozar, Abel; Zangi, Ronen; Cossio, Fernando P. Tetrahedron, 2013 , vol. 69, # 48 p. 10361 - 10368 1-(4'-metho... 76288-41-0 Trimethylapigen... Literature: Banerji, Asoke; Goomer, Naresh C. Synthesis, 1980 , # 11 p. 874 - 875 Flavokawain A Trimethylapigen... Literature: Smith, Jeffrey A.; Maloney, David J.; Hecht, Sidney M.; Lannigan, Deborah A. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 14 p. 5018 - 5034 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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