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(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide

Name: (R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide
Brand: 2A Biotech
SKU: 2A-1190179

CAS Number1492952-76-7

Synonymsasciminib; ABL-001

Molecular FormulaC20H18O3N5Cl1F2

Molecular Weight449.84

Density1.5±0.1 g/cm3

Boiling Point631.7±55.0 °C at 760 mmHg

MSDSChinese English

Cat. No.: 2A-1190179 Purity:

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Quality Control of [ 1492952-76-7 ] SDS Specification MoL

Chemical & Physical Properties
CAS Number	1492952-76-7
Catalog No.	2A-1190179
Chinese Name	阿思尼布
Synonyms	asciminib; ABL-001
Molecular Formula	C20H18O3N5Cl1F2
Molecular Weight	449.84
Density	1.5±0.1 g/cm3
Boiling Point	631.7±55.0 °C at 760 mmHg
Storage Condition	2-8℃
Application	Asciminib (ABL001) is a potent and selective allosteric Bcr-Abl inhibitor; inhibits the growth of Ba/F3 cells with an IC50 value of 0.25 nM.
PubChem ID	169551280
MDL Number	MFCD31560488
SMILES	O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC(O)C2)c(-c2ccn[nH]2)c1
InChI	InChI=1S/C20H18ClF2N5O3/c21-20(22,23)31-15-3-1-13(2-4-15)26-19(30)12-9-16(17-5-7-25-27-17)18(24-10-12)28-8-6-14(29)11-28/h1-5,7,9-10,14,29H,6,8,11H2,(H,25,27)(H,26,30)/t14-/m1/s1
InChI Key	VOVZXURTCKPRDQ-CQSZACIVSA-N
Transport Info	Product name: Asciminib (ABL001)

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(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide

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