| Chemical & Physical Properties | |
|---|---|
| CAS Number | 423763-19-3 |
| Catalog No. | 2A-2189834 |
| Chinese Name | 七乙二醇一苯甲醚 |
| Synonyms | 1-Phenyl-2,5,8,11,14,17,20-heptaoxadocosan-22-ol; monobenzyl heptaethylene glycol; Heptaethylene glycol Monobenzyl ether; Benzyl-PEG7-alcohol |
| Molecular Formula | C21H36O8 |
| Molecular Weight | 416.51 |
| Density | 1.099±0.06 g/cm3 |
| Boiling Point | 508.4±45.0 °C |
| Storage Condition | Room temperature, sealed, dry |
| Application | Benzyl-PEG7-alcohol is a PROTAC linker, belonging to the PEG class. Can be used to synthesize PROTAC molecules. |
| HTC | 2909499000 |
| PubChem ID | 37494253 |
| MDL Number | MFCD24682795 |
| SMILES | OCCOCCOCCOCCOCCOCCOCCOCc1ccccc1 |
| InChI | InChI=1S/C21H36O8/c22-6-7-23-8-9-24-10-11-25-12-13-26-14-15-27-16-17-28-18-19-29-20-21-4-2-1-3-5-21/h1-5,22H,6-20H2 |
| InChI Key | ZCSFSTZVHMIOOJ-UHFFFAOYSA-N |
| Use of | Benzyl-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name 2-[2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Synonym More Synonyms Benzyl-PEG7-alcohol Biological Activity Description Benzyl-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C21H36O8 Exact Mass 416.24100 PSA 84.84000 LogP 1.29510 InChIKey ZCSFSTZVHMIOOJ-UHFFFAOYSA-N Safety Information HS Code 2909499000 Synthetic Route Benzyl-PEG3-MS CAS#:702701-70-0 2,2'-((Oxybis(e... CAS#:112-60-7 Benzyl-PEG7-alcohol CAS#:423763-19-3 Benzyl-PEG7-THP CAS#:230620-75-4 Benzyl-PEG7-alcohol CAS#:423763-19-3 Literature: Burns, Christopher J.; Field, Leslie D.; Morgan, Jacqueline; Petteys, Brian J.; Prashar, Jognandan; Ridley, Damon D.; Sandanayake, K.R.A. Samankumara; Vignevich, Valentina Australian Journal of Chemistry, 2001 , vol. 54, # 7 p. 431 - 438 PEG8 benzyl ter... CAS#:1144113-13-2 Benzyl-PEG8-alcohol CAS#:477775-73-8 Benzyl-PEG7-alcohol CAS#:423763-19-3 Literature: French, Alister C.; Thompson, Amber L.; Davis, Benjamin G. Angewandte Chemie - International Edition, 2009 , vol. 48, # 7 p. 1248 - 1252 Precursor & DownStream Precursor 6 CAS#:702701-70-0 Benzyl-PEG3-MS CAS#:112-60-7 2,2'-((Oxybis(e... CAS#:1144113-13-2 PEG8 benzyl ter... CAS#:1050202-41-9 octaethylene gl... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
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