CAS Number764-22-7
Synonymserythro-Sphinganine; D-erythro-Sphinganine; 2-Aminooctadecane-1,3-diol; Dihydro-C18-sphingosine; (2S,3R)-2-aminooctadecane-1,3-diol; D-erythro-2-Amino-1,3-octadecanediol; 2-Amino-1,3-dihydroxyoctadecane; DL-erythro-2-Amino-1,3-octadecanediol; 2-Amino-1,3-octadecanediol; Octadephinganine; D-erythro-C18-Dihydrosphingosine; C18-Dihydrosphingosine; Dihydrosphingosine; DL-erythro-1,3-Dihydroxy-2-aminooctadecane
Molecular FormulaC18H39NO2
Molecular Weight301.51
Density0.9±0.1 g/cm3
Boiling Point446.2±25.0 °C at 760 mmHg
Melting Point70-72ºC
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 764-22-7 |
| Catalog No. | 2A-2189510 |
| Chinese Name | D-赤式-二氢鞘氨醇 |
| Synonyms | erythro-Sphinganine; D-erythro-Sphinganine; 2-Aminooctadecane-1,3-diol; Dihydro-C18-sphingosine; (2S,3R)-2-aminooctadecane-1,3-diol; D-erythro-2-Amino-1,3-octadecanediol; 2-Amino-1,3-dihydroxyoctadecane; DL-erythro-2-Amino-1,3-octadecanediol; 2-Amino-1,3-octadecanediol; Octadephinganine; D-erythro-C18-Dihydrosphingosine; C18-Dihydrosphingosine; Dihydrosphingosine; DL-erythro-1,3-Dihydroxy-2-aminooctadecane |
| Molecular Formula | C18H39NO2 |
| Molecular Weight | 301.51 |
| Density | 0.9±0.1 g/cm3 |
| Boiling Point | 446.2±25.0 °C at 760 mmHg |
| Melting Point | 70-72ºC |
| Storage Condition | -20°C |
| Application | D-Erythro-dihydrosphingosin directly inhibits phospholipase A2α (cPLA2α) activity in the cytosol. |
| PubChem ID | 4094 |
| MDL Number | MFCD07371371 |
| SMILES | CCCCCCCCCCCCCCCC(O)C(N)CO |
| InChI | InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1 |
| InChI Key | OTKJDMGTUTTYMP-ZWKOTPCHSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352211 |
| Hazard Symbols | transportation |
| Bioactivity | D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Cancer Natural Products >> Others Target Human Endogenous Metabolite In Vitro D-Erythro-dihydrosphingosine (D-erythro-DHS) significantly inhibits mastoparan-, but not Na3VO4-, stimulated arachidonic acid release in PC12 cells. D-Erythro-dihydrosphingosine at 100 AM slightly inhibits [3H]Arachidonic acid release, and 5 μM Ionomycin alone stimulates the release significantly. In the presence of 5 μM Ionomycin, 100 μM C2-ceramide stimulates the release, but D-Erythro-dihydrosphingosine (100 μM) inhibits the release. D-Erythro-dihydrosphingosine inhibits arachidonic acid release in cells and/or cPLA2α activity[1]. References [1]. Nakamura H, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004 Jan 19;484(1):9-17. Chemical & Physical Properties Density 0.9±0.1 g/cm3 Boiling Point 446.2±25.0 °C at 760 mmHg Melting Point 70-72ºC Molecular Formula C18H39NO2 Molecular Weight 301.508 Flash Point 223.7±23.2 °C Exact Mass 301.298065 PSA 66.48000 LogP 6.27 Vapour Pressure 0.0±2.4 mmHg at 25°C Index of Refraction 1.478 InChIKey OTKJDMGTUTTYMP-ZWKOTPCHSA-N SMILES CCCCCCCCCCCCCCCC(O)C(N)CO Storage condition -20°C |
| Use of | D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity. Properties Articles61 Name sphinganine Synonym More Synonyms 2-Amino-1,3-octadecanediol Biological Activity Description D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Cancer Natural Products >> Others Human Endogenous Metabolite References [1]. Nakamura H, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004 Jan 19;484(1):9-17. Chemical & Physical Properties Molecular Formula C18H39NO2 Exact Mass 301.298065 PSA 66.48000 Index of Refraction 1.478 InChIKey OTKJDMGTUTTYMP-ZWKOTPCHSA-N SMILES CCCCCCCCCCCCCCCC(O)C(N)CO |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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