| Chemical & Physical Properties | |
|---|---|
| CAS Number | 299430-87-8 |
| Catalog No. | 2A-1189034 |
| Chinese Name | 2-[2-(Fmoc-氨基)乙氧基]乙醇 |
| Synonyms | AmbotzFAL3010 |
| Molecular Formula | NH2CH2CH2OCH2CH2OH |
| Molecular Weight | 105.14 |
| Purity | 98.00 |
| Density | 1.221g/cm3 |
| Boiling Point | 547.8ºC at 760 mmHg |
| Storage Condition | 2-8°C |
| Application | Fmoc-N-amido-PEG2-alcohol is a PROTAC linker, belonging to the PEG class. Can be used to synthesize PROTAC molecules. |
| PubChem ID | 16512569 |
| SMILES | O=C(NCCOCCO)OCC1c2ccccc2-c2ccccc21 |
| InChI | InChI=1S/C19H21NO4/c21-10-12-23-11-9-20-19(22)24-13-18-16-7-3-1-5-14(16)15-6-2-4-8-17(15)18/h1-8,18,21H,9-13H2,(H,20,22) |
| InChI Key | DUVHQSUZTXSLMW-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Fmoc-N-amido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target PEGs In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Density 1.221g/cm3 Boiling Point 547.8ºC at 760 mmHg Molecular Formula C19H21NO4 Molecular Weight 327.37400 Flash Point 285.1ºC Exact Mass 327.14700 PSA 67.79000 LogP 2.92490 Vapour Pressure 7.81E-13mmHg at 25°C Index of Refraction 1.588 InChIKey DUVHQSUZTXSLMW-UHFFFAOYSA-N SMILES O=C(NCCOCCO)OCC1c2ccccc2-c2ccccc21 Storage condition 2-8°C |
| Use of | Fmoc-N-amido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name 9H-fluoren-9-ylmethyl N-[2-(2-hydroxyethoxy)ethyl]carbamate Synonym More Synonyms Fmoc-N-amido-PEG2-alcohol Biological Activity Description Fmoc-N-amido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C19H21NO4 Exact Mass 327.14700 PSA 67.79000 LogP 2.92490 Index of Refraction 1.588 InChIKey DUVHQSUZTXSLMW-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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