CAS Number119-36-8
Synonyms2-HYDROXY-BENZOIC ACID METHYL ESTER; 2-Hydroxybenzoic acid methyl ester; Benzoic acid, 2-hydroxy-, methyl ester; salicylic-acid methyl ester; Wintergreen oil (generic); 2-Hydroxybenzoic acid methyl ester,Methyl 2-hydroxybenzoate,Oil of wintergreen; METHYL SALICYLATE NF FCC; 2-Hydroxybenzoic acid methyl ester,Methyl 2-hydroxybenzoate,Methylis salicylas; 2-METHYL-5-(PROPAN-2-YL)PHENOL; methyl 2-hydroxybenzoate; Oil of wintergreen; methyl-2-hydroxybenzoate; methyl o-hydroxybenzoate; 2-hydroxymethylbenzoate; QR BVO1; 2-CARBOMETHOXYPHENOL; METHYL SALICYLATE NF; salicylic acid methyl ester; METHYL SALICYLATE: NF; Methyl salicylate; Wintergreen oil; METHYL SAL ICY LATE/METHYL 2-HYDROXYBENZOATE/SALICYLIC ACID METHYL ESTER; EINECS 204-317-7; MFCD00002214; methylsalicylate; SALICYLIC ACID METHYLESTE
Molecular Formula2-(HO)C6H4CO2CH3
Molecular Weight152.15
Purity≥98%
Density1.2±0.1 g/cm3
Boiling Point222 °C (lit.)
Melting Point−8-−7 °C (lit.)
Appearanceliquid
EINECS204-317-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 119-36-8 |
| Catalog No. | 2A-9019036 |
| Chinese Name | 水杨酸甲酯 |
| Synonyms | 2-HYDROXY-BENZOIC ACID METHYL ESTER; 2-Hydroxybenzoic acid methyl ester; Benzoic acid, 2-hydroxy-, methyl ester; salicylic-acid methyl ester; Wintergreen oil (generic); 2-Hydroxybenzoic acid methyl ester,Methyl 2-hydroxybenzoate,Oil of wintergreen; METHYL SALICYLATE NF FCC; 2-Hydroxybenzoic acid methyl ester,Methyl 2-hydroxybenzoate,Methylis salicylas; 2-METHYL-5-(PROPAN-2-YL)PHENOL; methyl 2-hydroxybenzoate; Oil of wintergreen; methyl-2-hydroxybenzoate; methyl o-hydroxybenzoate; 2-hydroxymethylbenzoate; QR BVO1; 2-CARBOMETHOXYPHENOL; METHYL SALICYLATE NF; salicylic acid methyl ester; METHYL SALICYLATE: NF; Methyl salicylate; Wintergreen oil; METHYL SAL ICY LATE/METHYL 2-HYDROXYBENZOATE/SALICYLIC ACID METHYL ESTER; EINECS 204-317-7; MFCD00002214; methylsalicylate; SALICYLIC ACID METHYLESTE |
| Molecular Formula | 2-(HO)C6H4CO2CH3 |
| Molecular Weight | 152.15 |
| Purity | ≥98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 222 °C (lit.) |
| Melting Point | −8-−7 °C (lit.) |
| Appearance | liquid |
| Water Solubility | 0.07 g/100 mL (20 ºC) |
| Storage Condition | 1. Packed in galvanized iron bucket or glass bottl |
| Packaging | III |
| Application | Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. It is also used as a pesticide, denaturant, spice ingredient and flavoring agent in food and tobacco products [1 |
| EINECS | 204-317-7 |
| HTC | 2918219000 |
| PubChem ID | 24901303 |
| MDL Number | MFCD00002214 |
| SMILES | COC(=O)c1ccccc1O |
| InChI | 1S/C8H8O3/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5,9H,1H3 |
| InChI Key | OSWPMRLSEDHDFF-UHFFFAOYSA-N |
| Beilstein/REAXYS | 971516 |
| NACRES Code | NA.21 |
| UNSPSC | 12164502 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/19036_1_119_36_8.pdf |
| Bioactivity | Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products[1]. A systemic acquired resistance (SAR) signal in tobacco[2]. A topical nonsteroidal anti-inflammatory drug (NSAID). Methyl salicylate lactoside is a COX inhibitor[4]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> COX Natural Products >> Acids and Aldehydes Research Areas >> Inflammation/Immunology In Vitro Methyl Salicylate is a systemic acquired resistance signal in tobacco. It (0-1 mg/L) esterases activity of salicylic acid-binding protein 2 (SABP2), which converts MeSA into salicylic acid (SA), is required for SAR signal perception in systemic tissue[2]. References [1]. Greene T, et al. A critical review of the literature to conduct a toxicity assessment for oral exposure to methyl salicylate. Crit Rev Toxicol. 2017 Feb;47(2):98-120. [2]. Park SW, et al. Methyl salicylate is a critical mobile signal for plant systemic acquired resistance. Science. 2007 Oct 5;318(5847):113-6. [3]. Lapczynski A, et al. Fragrance material review on methyl salicylate. Food Chem Toxicol. 2007;45 Suppl 1:S428-52. [4]. Xin W, et al. Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice. Br J Pharmacol. 2014 Jul;171(14):3526-38. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 222.0±0.0 °C at 760 mmHg Melting Point -8 °C Molecular Formula C8H8O3 Molecular Weight 152.147 Flash Point 86.8±12.6 °C Exact Mass 152.047348 PSA 46.53000 LogP 2.23 Vapour density 5.26 (vs air) Vapour Pressure 0.1±0.4 mmHg at 25°C Index of Refraction 1.547 InChIKey OSWPMRLSEDHDFF-UHFFFAOYSA-N SMILES COC(=O)c1ccccc1O Stability Stable. Incompatible with strong oxidizing agents, strong bases. Water Solubility 0.07 g/100 mL (20 ºC) |
| Use of | Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products[1]. A systemic acquired resistance (SAR) signal in tobacco[2]. A topical nonsteroidal anti-inflammatory drug (NSAID). Methyl salicylate lactoside is a COX inhibitor[4]. Properties Articles71 Name methyl salicylate Synonym More Synonyms Methyl salicylate Biological Activity Description Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products[1]. A systemic acquired resistance (SAR) signal in tobacco[2]. A topical nonsteroidal anti-inflammatory drug (NSAID). Methyl salicylate lactoside is a COX inhibitor[4]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> COX Natural Products >> Acids and Aldehydes Research Areas >> Inflammation/Immunology References [1]. Greene T, et al. A critical review of the literature to conduct a toxicity assessment for oral exposure to methyl salicylate. Crit Rev Toxicol. 2017 Feb;47(2):98-120. [2]. Park SW, et al. Methyl salicylate is a critical mobile signal for plant systemic acquired resistance. Science. 2007 Oct 5;318(5847):113-6. [3]. Lapczynski A, et al. Fragrance material review on methyl salicylate. Food Chem Toxicol. 2007;45 Suppl 1:S428-52. [4]. Xin W, et al. Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice. Br J Pharmacol. 2014 Jul;171(14):3526-38. Chemical & Physical Properties Molecular Formula C8H8O3 Exact Mass 152.047348 PSA 46.53000 Vapour density 5.26 (vs air) Index of Refraction 1.547 InChIKey OSWPMRLSEDHDFF-UHFFFAOYSA-N Stability Stable. Incompatible with strong oxidizing agents, strong bases. |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Chemical name |
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