| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2485-71-4 |
| Catalog No. | 2A-2188467 |
| Chinese Name | 13-甲基十四烷酸 |
| Synonyms | 13-Methylmyristic acid; 13-METHYLTETRADECANOIC ACID; 13-Methyltetradecanoic acid |
| Molecular Formula | C15H30O2 |
| Molecular Weight | 242.40 |
| Density | 0.894 g/cm3 |
| Boiling Point | 355.5ºC at 760 mmHg |
| Storage Condition | 2-8°C |
| Application | 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with powerful anti-cancer effects. 13-Methyltetradecanoic acid induces apoptosis in various types of human cancer cells [1][ |
| HTC | 2915900090 |
| PubChem ID | 6120954 |
| MDL Number | MFCD00083431 |
| SMILES | CC(C)CCCCCCCCCCCC(=O)O |
| InChI | InChI=1S/C15H30O2/c1-14(2)12-10-8-6-4-3-5-7-9-11-13-15(16)17/h14H,3-13H2,1-2H3,(H,16,17) |
| InChI Key | ZOCYQVNGROEVLU-UHFFFAOYSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352211 |
| Hazard Symbols | transportation |
| Bioactivity | 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer In Vitro 13-Methyltetradecanoic acid (13-MTD; 0-140 μg/mL; 12-24 hours) inhibits cell viability and proliferation in human bladder cancer cells by inducing apoptosis[1]. 13-Methyltetradecanoic acid (13-MTD; 70 μg/mL; 2-48 hours) treatments results in significant accumulation of cells with sub-G1 DNA content in a time-dependent manner, with the proportion of sub-G1 phase DNA content ranging from 9.25% to 85.3% over 2-48 hours[1]. 13-Methyltetradecanoic acid (13-MTD; 70 μg/mL; 2-24 hours) down-regulates Bcl-2 and up-regulates Bax. This promotes mitochondrial dysfunction, leading to the release of cytochrome c from the mitochondria to the cytoplasm, as well as the proteolytic activation of caspases. 13-Methyltetradecanoic acid down-regulates AKT phosphorylation and activates phosphorylation of p38 and c-Jun N-terminal kinase (JNK)[1]. Cell Viability Assay[1] Cell Line: Bladder cancer cell lines T24, 5637, and UM-UC-3 Concentration: 0 μg/mL, 35 μg/mL, 70 μg/mL, 105 μg/mL, and 140 μg/mL Incubation Time: 12 hours, 24 hours Result: Inhibition of cell viability in a dose- and time-dependent manner. Cell Cycle Analysis[1] Cell Line: Bladder cancer cell lines T24, 5637, and UM-UC-3 Concentration: 70 μg/mL Incubation Time: 2 hours, 8 hours, 24 hours, or 48 hours Result: Resulted in significant accumulation of cells with sub-G1 DNA content in a time-dependent manner. Western Blot Analysis[1] Cell Line: T24, 5637, and UM-UC-3 cells Concentration: 70 μg/mL Incubation Time: 2 hours, 8 hours, 24 hours Result: Down-regulated Bcl-2 and up-regulated Bax, and down-regulated AKT phosphorylation and activated phosphorylation of p38 and c-Jun N-terminal kinase (JNK). In Vivo 13-Methyltetradecanoic acid (13-MTD; 70 mg/kg/day; oral gavage; daily; for 30 days) significantly suppresses tumor growth in a xenograft model[2]. Animal Model: BALB/C nude mice injected with Jurkat lymphoma cells[2] Dosage: 70 mg/kg/day Administration: Oral gavage; daily; for 30 days Result: Effectively inhibited the growth in vivo in a xenograft model. References [1]. Tianxin Lin, et al. 13-Methyltetradecanoic acid induces mitochondrial-mediated apoptosis in human bladder cancer cells. Urol Oncol. May-Jun 2012;30(3):339-45. [2]. Qingqing Cai, et al. 13-methyltetradecanoic acid exhibits anti-tumor activity on T-cell lymphomas in vitro and in vivo by down-regulating p-AKT and activating caspase-3. PLoS One. 2013 Jun 7;8(6):e65308. Chemical & Physical Properties Density 0.894 g/cm3 Boiling Point 355.5ºC at 760 mmHg Molecular Formula C15H30O2 Molecular Weight 242.40 Flash Point 197.4ºC Exact Mass 242.22500 PSA 37.30000 LogP 5.01810 Vapour Pressure 5.19E-06mmHg at 25°C Index of Refraction 1.451 InChIKey ZOCYQVNGROEVLU-UHFFFAOYSA-N SMILES CC(C)CCCCCCCCCCCC(=O)O Storage condition 2-8°C |
| Use of | 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells[1][2]. Properties Articles13 Name isopentadecanoic acid Synonym More Synonyms 13-Methyltetradecanoic acid Biological Activity Description 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer References [1]. Tianxin Lin, et al. 13-Methyltetradecanoic acid induces mitochondrial-mediated apoptosis in human bladder cancer cells. Urol Oncol. May-Jun 2012;30(3):339-45. [2]. Qingqing Cai, et al. 13-methyltetradecanoic acid exhibits anti-tumor activity on T-cell lymphomas in vitro and in vivo by down-regulating p-AKT and activating caspase-3. PLoS One. 2013 Jun 7;8(6):e65308. Chemical & Physical Properties Molecular Formula C15H30O2 Exact Mass 242.22500 PSA 37.30000 LogP 5.01810 Index of Refraction 1.451 InChIKey ZOCYQVNGROEVLU-UHFFFAOYSA-N SMILES CC(C)CCCCCCCCCCCC(=O)O |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Imported food hygiene supervision and inspection S. Export food hygiene supervision and inspection M. Imported commodity inspection N. Exported commodity inspection |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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